23BD
Caspase-4 p22/p10 and human GSDMD complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009306 | biological_process | protein secretion |
| A | 0022829 | molecular_function | wide pore channel activity |
| A | 0031966 | cellular_component | mitochondrial membrane |
| A | 0032731 | biological_process | positive regulation of interleukin-1 beta production |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0046931 | biological_process | pore complex assembly |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0051260 | biological_process | protein homooligomerization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0061702 | cellular_component | canonical inflammasome complex |
| A | 0070269 | biological_process | pyroptotic inflammatory response |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| A | 0070300 | molecular_function | phosphatidic acid binding |
| A | 0072559 | cellular_component | NLRP3 inflammasome complex |
| A | 0141201 | biological_process | pyroptotic cell death |
| A | 1901612 | molecular_function | cardiolipin binding |
| A | 1904724 | cellular_component | tertiary granule lumen |
| A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PROSITE/UniProt
| site_id | PS01121 |
| Number of Residues | 15 |
| Details | CASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG |
| Chain | Residue | Details |
| B | HIS197-GLY211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P29466","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"22246630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23661706","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25119034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7743998","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Propeptide: {"featureId":"PRO_0000004598","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7797510","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"34671164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36624349","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by papain","evidences":[{"source":"PubMed","id":"35794369","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"32820063","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"37962578","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"40097387","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
