1ZYS
Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase Chk1 | polymer | 273 | 31399.1 | 1 | UniProt (O14757) Pfam (PF00069) In PDB | Homo sapiens (human) | Checkpoint Kinase Chk1 |
| 2 | B | pentapeptide fragment | polymer | 5 | 433.5 | 1 | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | A | N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE | non-polymer | 412.5 | 1 | Chemie (199) | |||
| 5 | water | water | 18.0 | 338 | Chemie (HOH) |
Sequence modifications
A: 1 - 273 (UniProt: O14757)
| PDB | External Database | Details |
|---|---|---|
| Ala 60 | Lys 60 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31832.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 508.6 | |
| All* | Total formula weight | 32341.2 |
