1Z2B
Tubulin-colchicine-vinblastine: stathmin-like domain complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha chain | polymer | 448 | 49947.2 | 2 | GenBank (59858433) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q2HJ86) | Bos taurus (cattle) | |
| 2 | B, D (B, D) | Tubulin beta chain | polymer | 445 | 49937.7 | 2 | GenBank (50844501) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q6B856) | Bos taurus (cattle) | |
| 3 | E (E) | RB3 STATHMIN-LIKE DOMAIN 4 | polymer | 142 | 16713.0 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway rat) | Stathmin-like protein B3, RB3-SLD |
| 4 | F, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G, K (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | H, M (B, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 7 | I, N (B, D) | 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE | non-polymer | 431.5 | 2 | Chemie (CN2) PubChem (21158775) PubChem (5287955) | |||
| 8 | L (C) | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE | non-polymer | 811.0 | 1 | Chemie (VLB) |
Sequence modifications
A, C: 1 - 448 (GenBank: 59858433)
B, D: 1 - 445 (GenBank: 50844501)
E: 5 - 145 (UniProt: P63043)
| PDB | External Database | Details |
|---|---|---|
| Ile 7 | Val 7 | SEE REMARK 999 |
| Ile 16 | Met 16 | SEE REMARK 999 |
| Asn 50 | Thr 50 | SEE REMARK 999 |
| Ser 54 | Cys 54 | SEE REMARK 999 |
| Val 78 | Ile 78 | SEE REMARK 999 |
| Thr 80 | Asn 80 | SEE REMARK 999 |
| Thr 82 | Pro 82 | SEE REMARK 999 |
| Leu 117 | Pro 117 | SEE REMARK 999 |
| Ala 126 | Ser 126 | SEE REMARK 999 |
| Gly 232 | Ser 232 | SEE REMARK 999 |
| Thr 334 | Ala 334 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Val 172 | Met 170 | SEE REMARK 999 |
| Val 318 | Ile 316 | SEE REMARK 999 |
| PDB | External Database | Details |
|---|---|---|
| Ala 4 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 216482.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3655.3 | |
| All* | Total formula weight | 220138.1 |
