1Z2B

Tubulin-colchicine-vinblastine: stathmin-like domain complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Tubulin alpha chain	polymer	448	49947.2	2	GenBank (59858433) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q2HJ86) In PDB	Bos taurus (cattle)
2	B, D	Tubulin beta chain	polymer	445	49937.7	2	GenBank (50844501) Pfam (PF00091) Pfam (PF03953) UniProt (by SIFTS) (Q6B856) In PDB	Bos taurus (cattle)
3	E	RB3 STATHMIN-LIKE DOMAIN 4	polymer	142	16713.0	1	UniProt (P63043) Pfam (PF00836) In PDB	Rattus norvegicus (Norway rat)	Stathmin-like protein B3, RB3-SLD
4	A, C	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5	A, C	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
6	B, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
7	B, D	2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	non-polymer		431.5	2	Chemie (CN2)
8	C	(2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE	non-polymer		811.0	1	Chemie (VLB)

Sequence modifications

A, C: 1 - 448 (GenBank: 59858433)

PDB	External Database	Details
Ile 7	Val 7	SEE REMARK 999
Ile 16	Met 16	SEE REMARK 999
Asn 50	Thr 50	SEE REMARK 999
Ser 54	Cys 54	SEE REMARK 999
Val 78	Ile 78	SEE REMARK 999
Thr 80	Asn 80	SEE REMARK 999
Thr 82	Pro 82	SEE REMARK 999
Leu 117	Pro 117	SEE REMARK 999
Ala 126	Ser 126	SEE REMARK 999
Gly 232	Ser 232	SEE REMARK 999
Thr 334	Ala 334	SEE REMARK 999

B, D: 1 - 445 (GenBank: 50844501)

PDB	External Database	Details
Val 172	Met 170	SEE REMARK 999
Val 318	Ile 316	SEE REMARK 999

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Ala 4	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	216482.7
Non-Polymers*	Number of molecules	9
	Total formula weight	3655.3
All*	Total formula weight	220138.1

*Water molecules are not included.