1XSN
Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | T | 5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3' | polymer | 11 | 3358.2 | 1 | |||
| 2 | P | 5'-D(*CP*AP*GP*TP*AP*(2DT))-3' | polymer | 6 | 1792.2 | 1 | |||
| 3 | D | 5'-D(P*GP*CP*CP*G)-3' | polymer | 4 | 1191.8 | 1 | |||
| 4 | A | DNA polymerase lambda | polymer | 335 | 37447.7 | 1 | UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791) In PDB | Homo sapiens (human) | Pol Lambda, DNA polymerase beta-2, Pol beta2 |
| 5 | T, P | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 8 | A | 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 466.2 | 1 | Chemie (D3T) | |||
| 9 | water | water | 18.0 | 327 | Chemie (HOH) |
Sequence modifications
A: 242 - 575 (UniProt: Q9UGP5)
| PDB | External Database | Details |
|---|---|---|
| Met 241 | - | initiating methionine |
| Ala 543 | Cys 543 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43789.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 784.7 | |
| All* | Total formula weight | 44574.7 |
