1XSN

Crystal Structure of human DNA polymerase lambda in complex with a one nucleotide DNA gap and ddTTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 576

Chain	Residue
A	ASP427
A	ASP429
A	D3T579
A	HOH586

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 577

Chain	Residue
P	HOH2807
A	SER339
A	ILE341
A	ALA344
A	HOH582
P	DA5

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 578

Chain	Residue
A	SER463
A	HOH617
A	HOH721
A	HOH722
T	HOH190

---

site_id	AC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE D3T A 579

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	TYR505
A	PHE506
A	GLY508
A	ALA510
A	ASN513
A	MG576
A	HOH580
A	HOH586
A	HOH636
A	HOH638
A	HOH647
A	HOH708
P	2DT6
T	DA5

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO P 2801

Chain	Residue
A	MET351
A	ARG485
P	DG3
P	HOH2832

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO P 2802

Chain	Residue
A	GLU361
P	DC1
P	DA2
P	HOH2820

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO T 2803

Chain	Residue
A	THR534
A	ALA535
A	ARG549
T	DC1

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO P 2804

Chain	Residue
P	DT4
P	DA5
P	HOH2816
P	HOH2817
P	HOH2819

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
A	SER417
A	GLY426
A	ASN513

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
A	ASP429
A	ASP490

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

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