1U67
Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prostaglandin G/H synthase 1 precursor | polymer | 600 | 68784.0 | 1 | UniProt (P05979) Pfam (PF03098) | Ovis aries (sheep) | Cyclooxygenase-1, COX-1, Prostaglandin-endoperoxide synthase 1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1 |
| 2 | B, D (B, D) | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G07375KG) | |||
| 3 | C (C) | beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G40894EI) | |||
| 4 | E, F, G, H (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 4 | Chemie (BOG) | |||
| 5 | I (A) | PROTOPORPHYRIN IX CONTAINING CO | non-polymer | 619.6 | 1 | Chemie (COH) | |||
| 6 | J (A) | ARACHIDONIC ACID | non-polymer | 304.5 | 1 | Chemie (ACD) | |||
| 7 | K (A) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A: 1 - 600 (UniProt: P05979)
| PDB | External Database | Details |
|---|---|---|
| Leu 92 | Met 92 | see remark 999 |
| Ala 349 | Val 349 | engineered mutation |
| Phe 387 | Trp 387 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 68784.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2093.5 | |
| All* | Total formula weight | 72475.0 |
