1U32
Crystal structure of a Protein Phosphatase-1: Calcineurin Hybrid Bound to Okadaic Acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine protein phosphatase PP1-gamma catalytic subunit | polymer | 293 | 33771.9 | 1 | UniProt (P36873) Pfam (PF16891) Pfam (PF00149) In PDB | Homo sapiens (human) | Protein Phosphatase-1: Calcineurin hybrid, PP-1G, Protein phosphatase 1C catalytic subunit |
| 2 | A | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 3 | A | OKADAIC ACID | non-polymer | 805.0 | 1 | Chemie (OKA) | |||
| 4 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 3 | Chemie (BME) | |||
| 5 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 6 - 298 (UniProt: P36873)
| PDB | External Database | Details |
|---|---|---|
| Leu 273 | Cys 273 | engineered mutation |
| Asp 274 | Gly 274 | engineered mutation |
| Val 275 | Glu 275 | engineered mutation |
| Tyr 276 | Phe 276 | engineered mutation |
| Asn 277 | Asp 277 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33771.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1149.3 | |
| All* | Total formula weight | 34921.2 |
