1TN6
Protein Farnesyltransferase Complexed with a Rap2a Peptide Substrate and a FPP Analog at 1.8A Resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein farnesyltransferase alpha subunit | polymer | 382 | 44864.8 | 1 | UniProt (P49354) Pfam (PF01239) | Homo sapiens (human) | CAAX farnesyltransferase alpha subunit, FTase-alpha |
| 2 | B (B) | Protein farnesyltransferase beta subunit | polymer | 437 | 48822.4 | 1 | UniProt (P49356) Pfam (PF00432) | Homo sapiens (human) | CAAX farnesyltransferase beta subunit, FTase-beta |
| 3 | C (C) | peptide derived from the C-terminus of Rap2a | polymer | 11 | 1134.2 | 1 | |||
| 4 | D (D) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900003) | sucrose | ||
| 5 | E, H (A, B) | ACETIC ACID | non-polymer | 60.1 | 2 | Chemie (ACY) | |||
| 6 | F (B) | [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID | non-polymer | 359.4 | 1 | Chemie (FII) | |||
| 7 | G (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | I, J, K (A, B, C) | water | water | 18.0 | 659 | Chemie (HOH) |
Sequence modifications
A: 1 - 379 (UniProt: P49354)
| PDB | External Database | Details |
|---|---|---|
| Glu 380 | - | insertion |
| Glu 381 | - | insertion |
| Phe 382 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 94821.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 544.9 | |
| All* | Total formula weight | 95708.6 |
