1T2A
Crystal structure of human GDP-D-mannose 4,6-dehydratase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | GDP-mannose 4,6 dehydratase | polymer | 375 | 42699.3 | 4 | UniProt (O60547) Pfam (PF16363) | Homo sapiens (human) | GDP-D-mannose dehydratase, GMD |
| 2 | E, G, I, K (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | F, H, J, L (A, B, C, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 998 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 23 - 372 (UniProt: O60547)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | cloning artifact |
| Gly 1 | - | cloning artifact |
| Ser 3 | - | cloning artifact |
| Ser 3 | - | cloning artifact |
| His 5 | - | cloning artifact |
| His 6 | - | cloning artifact |
| His 7 | - | cloning artifact |
| His 8 | - | cloning artifact |
| His 9 | - | cloning artifact |
| His 9 | - | cloning artifact |
| Ser 11 | - | cloning artifact |
| Ser 11 | - | cloning artifact |
| Gly 12 | - | cloning artifact |
| Arg 13 | - | cloning artifact |
| Glu 14 | - | cloning artifact |
| Asn 15 | - | cloning artifact |
| Lys 16 | - | cloning artifact |
| Tyr 17 | - | cloning artifact |
| Phe 18 | - | cloning artifact |
| Gln 19 | - | cloning artifact |
| Gly 20 | - | cloning artifact |
| His 21 | - | cloning artifact |
| Met 22 | - | cloning artifact |
| Gly 373 | - | cloning artifact |
| Ser 374 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 170797.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4754.5 | |
| All* | Total formula weight | 175551.6 |
