1R6T
crystal structure of human tryptophanyl-tRNA synthetase
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tryptophanyl-tRNA synthetase | polymer | 477 | 54375.6 | 2 | UniProt (P23381) Pfam (PF00458) Pfam (PF00579) In PDB | Homo sapiens (human) | Tryptophan--tRNA ligase, TrpRS, IFP53, hWRS |
2 | A | TRYPTOPHANYL-5'AMP | non-polymer | 533.4 | 1 | Chemie (TYM) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 466 (UniProt: P23381)
PDB | External Database | Details |
---|---|---|
Mse 42 | Met 42 | modified residue |
Mse 48 | Met 48 | modified residue |
Mse 143 | Met 143 | modified residue |
Mse 169 | Met 169 | modified residue |
Mse 195 | Met 195 | modified residue |
Gly 213 | Ser 213 | engineered mutation |
Asp 214 | Tyr 214 | engineered mutation |
Mse 241 | Met 241 | modified residue |
Mse 243 | Met 243 | modified residue |
Mse 319 | Met 319 | modified residue |
Mse 350 | Met 350 | modified residue |
Mse 401 | Met 401 | modified residue |
Mse 425 | Met 425 | modified residue |
Mse 461 | Met 461 | modified residue |
Ala 467 | - | cloning artifact |
Ala 468 | - | cloning artifact |
Ala 469 | - | cloning artifact |
Leu 470 | - | cloning artifact |
Glu 471 | - | cloning artifact |
His 472 | - | expression tag |
His 473 | - | expression tag |
His 474 | - | expression tag |
His 475 | - | expression tag |
His 476 | - | expression tag |
His 477 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 108751.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 717.6 | |
All* | Total formula weight | 109468.8 |