1R6T

crystal structure of human tryptophanyl-tRNA synthetase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tryptophanyl-tRNA synthetase	polymer	477	54375.6	2	UniProt (P23381) Pfam (PF00458) Pfam (PF00579)	Homo sapiens (human)	Tryptophan--tRNA ligase, TrpRS, IFP53, hWRS
2	C (A)	TRYPTOPHANYL-5'AMP	non-polymer		533.4	1	Chemie (TYM)
3	D, E (A, B)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	F, G (A, B)	water	water		18.0	294	Chemie (HOH)

Sequence modifications

A, B: 1 - 466 (UniProt: P23381)

PDB	External Database	Details
Mse 42	Met 42	modified residue
Mse 48	Met 48	modified residue
Mse 143	Met 143	modified residue
Mse 169	Met 169	modified residue
Mse 195	Met 195	modified residue
Gly 213	Ser 213	engineered mutation
Asp 214	Tyr 214	engineered mutation
Mse 241	Met 241	modified residue
Mse 243	Met 243	modified residue
Mse 319	Met 319	modified residue
Mse 350	Met 350	modified residue
Mse 401	Met 401	modified residue
Mse 425	Met 425	modified residue
Mse 461	Met 461	modified residue
Ala 467	-	cloning artifact
Ala 468	-	cloning artifact
Ala 469	-	cloning artifact
Leu 470	-	cloning artifact
Glu 471	-	cloning artifact
His 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108751.2
Non-Polymers*	Number of molecules	3
	Total formula weight	717.6
All*	Total formula weight	109468.8

*Water molecules are not included.