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1R6T

crystal structure of human tryptophanyl-tRNA synthetase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001525biological_processangiogenesis
A0004812molecular_functionaminoacyl-tRNA ligase activity
A0004830molecular_functiontryptophan-tRNA ligase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006412biological_processtranslation
A0006418biological_processtRNA aminoacylation for protein translation
A0006436biological_processtryptophanyl-tRNA aminoacylation
A0006469biological_processnegative regulation of protein kinase activity
A0008285biological_processnegative regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0016874molecular_functionligase activity
A0019210molecular_functionkinase inhibitor activity
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0031334biological_processpositive regulation of protein-containing complex assembly
A0032991cellular_componentprotein-containing complex
A0042803molecular_functionprotein homodimerization activity
A0045765biological_processregulation of angiogenesis
A0070062cellular_componentextracellular exosome
B0000166molecular_functionnucleotide binding
B0001525biological_processangiogenesis
B0004812molecular_functionaminoacyl-tRNA ligase activity
B0004830molecular_functiontryptophan-tRNA ligase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006412biological_processtranslation
B0006418biological_processtRNA aminoacylation for protein translation
B0006436biological_processtryptophanyl-tRNA aminoacylation
B0006469biological_processnegative regulation of protein kinase activity
B0008285biological_processnegative regulation of cell population proliferation
B0010628biological_processpositive regulation of gene expression
B0016874molecular_functionligase activity
B0019210molecular_functionkinase inhibitor activity
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0031334biological_processpositive regulation of protein-containing complex assembly
B0032991cellular_componentprotein-containing complex
B0042803molecular_functionprotein homodimerization activity
B0045765biological_processregulation of angiogenesis
B0070062cellular_componentextracellular exosome
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE TYM A 501
ChainResidue
ATYR159
AGLU199
AGLN284
AALA310
AASP312
AGLN313
APHE317
APHE339
APHE340
ALYS349
AMSE350
ATHR160
AHOH1002
AHOH1007
AHOH1018
AHOH1028
AHOH1044
AHOH1113
AGLY161
AARG162
AGLY163
AGLY172
AHIS173
APRO176
AGLN194

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 601
ChainResidue
ALYS253
AARG326
AILE327
BTYR201
BTHR207
BLEU208
BHOH1138
BHOH1213
BHOH1285

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 602
ChainResidue
AASP101
ALYS111
AGLY135
APHE138

Functional Information from PROSITE/UniProt
site_idPS00178
Number of Residues11
DetailsAA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Ps.SEaMHVGHL
ChainResidueDetails
APRO164-LEU174

site_idPS00762
Number of Residues29
DetailsWHEP_TRS_1 WHEP-TRS domain signature. QGElVRslKagNAskdeIDsaVkmLvslK
ChainResidueDetails
AGLN19-LYS47

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P32921
ChainResidueDetails
ALYS154
BLYS154

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER351
BSER351

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1d2r
ChainResidueDetails
AALA352
ALYS349

237735

PDB entries from 2025-06-18

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