1PQ2
Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cytochrome P450 2C8 | polymer | 476 | 54054.2 | 2 | UniProt (P10632) Pfam (PF00067) | Homo sapiens (human) | CYPIIC8, P450 form 1, P450 MP- 12/MP-20, P450 IIC2, S-mephenytoin 4-hydroxylase |
| 2 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | D, G (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 4 | E, F (A, B) | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 490 (UniProt: P10632)
| PDB | External Database | Details |
|---|---|---|
| Met 19 | - | engineered mutation |
| Ala 20 | - | engineered mutation |
| Lys 21 | - | engineered mutation |
| Lys 22 | - | engineered mutation |
| Thr 23 | - | engineered mutation |
| Ser 24 | - | engineered mutation |
| Ser 25 | - | engineered mutation |
| Lys 26 | - | engineered mutation |
| Gly 27 | - | engineered mutation |
| His 491 | - | expression tag |
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 108108.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1840.8 | |
| All* | Total formula weight | 109949.1 |
