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1PQ2

Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

Functional Information from GO Data
ChainGOidnamespacecontents
A0002933biological_processlipid hydroxylation
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006082biological_processorganic acid metabolic process
A0006629biological_processlipid metabolic process
A0006721biological_processterpenoid metabolic process
A0006805biological_processxenobiotic metabolic process
A0008202biological_processsteroid metabolic process
A0008210biological_processestrogen metabolic process
A0008392molecular_functionarachidonate epoxygenase activity
A0008401molecular_functionretinoic acid 4-hydroxylase activity
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0019369biological_processarachidonate metabolic process
A0019373biological_processepoxygenase P450 pathway
A0020037molecular_functionheme binding
A0032787biological_processmonocarboxylic acid metabolic process
A0034875molecular_functioncaffeine oxidase activity
A0042178biological_processxenobiotic catabolic process
A0042572biological_processretinol metabolic process
A0042573biological_processretinoic acid metabolic process
A0042759biological_processlong-chain fatty acid biosynthetic process
A0046456biological_processicosanoid biosynthetic process
A0046872molecular_functionmetal ion binding
A0070989biological_processoxidative demethylation
A0097267biological_processomega-hydroxylase P450 pathway
A0101020molecular_functionestrogen 16-alpha-hydroxylase activity
B0002933biological_processlipid hydroxylation
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006082biological_processorganic acid metabolic process
B0006629biological_processlipid metabolic process
B0006721biological_processterpenoid metabolic process
B0006805biological_processxenobiotic metabolic process
B0008202biological_processsteroid metabolic process
B0008210biological_processestrogen metabolic process
B0008392molecular_functionarachidonate epoxygenase activity
B0008401molecular_functionretinoic acid 4-hydroxylase activity
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B0019369biological_processarachidonate metabolic process
B0019373biological_processepoxygenase P450 pathway
B0020037molecular_functionheme binding
B0032787biological_processmonocarboxylic acid metabolic process
B0034875molecular_functioncaffeine oxidase activity
B0042178biological_processxenobiotic catabolic process
B0042572biological_processretinol metabolic process
B0042573biological_processretinoic acid metabolic process
B0042759biological_processlong-chain fatty acid biosynthetic process
B0046456biological_processicosanoid biosynthetic process
B0046872molecular_functionmetal ion binding
B0070989biological_processoxidative demethylation
B0097267biological_processomega-hydroxylase P450 pathway
B0101020molecular_functionestrogen 16-alpha-hydroxylase activity
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 A 504
ChainResidue
AILE331
AHIS334
AARG335

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE HEM A 500
ChainResidue
AGLY298
ATHR301
AGLN356
ALEU361
AVAL366
AHIS368
APHE428
ASER429
AARG433
ACYS435
AALA436
AALA441
AARG97
AILE112
ATRP120
AARG124
ALEU131
AALA297

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PLM B 501
ChainResidue
AARG105
AILE106
ATHR229
AHIS230
ALEU234
BPHE226
BPRO227
BGLY228
BTHR229
BHOH601

site_idAC4
Number of Residues21
DetailsBINDING SITE FOR RESIDUE HEM B 500
ChainResidue
BARG97
BILE112
BILE113
BTRP120
BARG124
BLEU294
BALA297
BGLY298
BTHR301
BTHR302
BTHR305
BLEU361
BHIS368
BPRO427
BPHE428
BSER429
BARG433
BCYS435
BALA436
BGLY437
BALA441

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PLM A 502
ChainResidue
APHE226
APRO227
AGLY228
ATHR229
BARG105
BILE106
BTRP212
BCYS216
BILE223
BTHR229
BLEU234

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSaGKRICAG
ChainResidueDetails
APHE428-GLY437

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"description":"axial binding residue"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
AGLU300
ATHR301

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1akd
ChainResidueDetails
BGLU300
BTHR301

239803

PDB entries from 2025-08-06

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