1P1W

Crystal structure of the GluR2 ligand-binding core (S1S2J) with the L483Y and L650T mutations and in complex with AMPA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glutamate receptor 2 precursor	polymer	263	29259.6	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2
2	C, E (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, F (A, B)	(S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID	non-polymer		186.2	2	Chemie (AMQ)
4	G, H (A, B)	water	water		18.0	235	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	cloning artifact
Ala 2	-	cloning artifact
Tyr 94	Leu 504	engineered mutation

A, B: 120 - 263 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	insertion
Thr 119	-	insertion
Thr 138	Leu 672	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58519.3
Non-Polymers*	Number of molecules	4
	Total formula weight	564.5
All*	Total formula weight	59083.7

*Water molecules are not included.