1P0S
Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor X precursor | polymer | 138 | 16070.3 | 1 | UniProt (P00742) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | Stuart factor |
| 2 | B (H) | Coagulation factor X precursor | polymer | 254 | 28550.6 | 1 | UniProt (P00742) Pfam (PF00089) | Homo sapiens (human) | Stuart factor |
| 3 | C (E) | Ecotin precursor | polymer | 142 | 16146.5 | 1 | UniProt (P23827) Pfam (PF03974) | Escherichia coli | |
| 4 | D, E, F, G (L, H) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | H (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | I, J, K (L, H, E) | water | water | 18.0 | 51 | Chemie (HOH) |
Sequence modifications
L: 1 - 138 (UniProt: P00742)
E: 1 - 142 (UniProt: P23827)
| PDB | External Database | Details |
|---|---|---|
| Cgu 6 | Glu 46 | modified residue |
| Cgu 7 | Glu 47 | modified residue |
| Cgu 14 | Glu 54 | modified residue |
| Cgu 16 | Glu 56 | modified residue |
| Cgu 19 | Glu 59 | modified residue |
| Cgu 20 | Glu 60 | modified residue |
| Cgu 25 | Glu 65 | modified residue |
| Cgu 26 | Glu 66 | modified residue |
| Cgu 29 | Glu 69 | modified residue |
| Cgu 32 | Glu 72 | modified residue |
| Cgu 39 | Glu 79 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Arg 84 | Met 104 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60767.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 120.2 | |
| All* | Total formula weight | 60887.6 |
