1P0S

Crystal Structure of Blood Coagulation Factor Xa in Complex with Ecotin M84R

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004867	molecular_function	serine-type endopeptidase inhibitor activity
E	0005515	molecular_function	protein binding
E	0006952	biological_process	defense response
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0030414	molecular_function	peptidase inhibitor activity
E	0042597	cellular_component	periplasmic space
E	0042803	molecular_function	protein homodimerization activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis
L	0005509	molecular_function	calcium ion binding
L	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG L 139

Chain	Residue
E	GLN5
L	CGU16
L	CGU26

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG L 140

Chain	Residue
L	CGU14
L	CGU19
L	HOH148

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG L 141

Chain	Residue
L	CGU25
L	CGU29
L	HOH144

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 265

Chain	Residue
H	ASP70
H	ASN72
H	GLN75
H	GLU76
H	GLU80
H	HOH273

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA H 266

Chain	Residue
H	TYR185
H	ASP185
H	ARG222
H	LYS224

---

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CkDglgeYtCtC

Chain	Residue	Details
L	CYS61-CYS72

---

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEtCsyeearEvfedsdktne.FW

Chain	Residue	Details
L	CGU16-TRP41

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CtCleGfeGKnC

Chain	Residue	Details
L	CYS70-CYS81

---

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV

Chain	Residue	Details
H	ASP189-VAL200

---

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CtCleGFegkn....C

Chain	Residue	Details
L	CYS70-CYS81
L	CYS109-CYS124

---

site_id	PS01187
Number of Residues	25
Details	EGF_CA Calcium-binding EGF-like domain signature. DgDQCetsp..........Cqnqgk..CkDglgeYtC

Chain	Residue	Details
L	ASP46-CYS70

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Reactive bond

Chain	Residue	Details
E	ARG84
L	CGU32
L	CGU39
H	ASP102
H	SER195
L	CGU16
L	CGU19
L	CGU20
L	CGU25
L	CGU26
L	CGU29

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: (3R)-3-hydroxyaspartate => ECO:0000269|PubMed:6871167

Chain	Residue	Details
L	ASP63

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	HIS57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY196

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY193

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	GLY193
H	HIS57

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	ASP100
H	GLY193
H	HIS57

---

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57
H	GLY196

---