1OMW

Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	G-protein coupled receptor kinase 2	polymer	689	79749.9	1	UniProt (P21146) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169)	Bos taurus (cattle)	GRK2, Beta-ARK-1, Beta-adrenergic receptor kinase 1
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 1	polymer	340	37416.9	1	UniProt (P62871) Pfam (PF00400)	Bos taurus (cattle)	Transducin beta chain 1
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	polymer	74	8406.7	1	UniProt (P63212) Pfam (PF00631)	Bos taurus (cattle)	G gamma-I
4	D, E, F (A, B, G)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 1 - 689 (UniProt: P21146)

PDB	External Database	Details
Ala 670	Ser 670	engineered mutation

G: 1 - 68 (UniProt: P63212)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Cmt 68	Cys 67	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	125573.5
All*	Total formula weight	125573.5

*Water molecules are not included.