1NL0

Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	anti-factor IX antibody, 10C12, chain L	polymer	213	22631.0	1		Homo sapiens (human)
2	H	anti-factor IX antibody, 10C12, chain H	polymer	224	23800.9	1		Homo sapiens (human)
3	G	factor IX	polymer	51	7117.9	1	UniProt (P00740) Pfam (PF00594) In PDB
4	L	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	G	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
6		water	water		18.0	148	Chemie (HOH)

Sequence modifications

G: 1 - 45 (UniProt: P00740)

PDB	External Database	Details
Cgu 7	Glu 53	modified residue
Cgu 8	Glu 54	modified residue
Cgu 15	Glu 61	modified residue
Cgu 17	Glu 63	modified residue
Cgu 20	Glu 66	modified residue
Cgu 21	Glu 67	modified residue
Cgu 26	Glu 72	modified residue
Cgu 27	Glu 73	modified residue
Cgu 30	Glu 76	modified residue
Cgu 33	Glu 79	modified residue
Cgu 36	Glu 82	modified residue
Cgu 40	Glu 86	modified residue
Cgu 46	-	cloning artifact
Cgu 47	-	cloning artifact
Cgu 48	-	cloning artifact
Cgu 49	-	cloning artifact
Cgu 50	-	cloning artifact
Cgu 51	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53549.8
Non-Polymers*	Number of molecules	7
	Total formula weight	336.5
All*	Total formula weight	53886.3

*Water molecules are not included.