1NL0

Crystal structure of human factor IX Gla domain in complex of an inhibitory antibody, 10C12

Functional Information from GO Data

Chain	GOid	namespace	contents
G	0005509	molecular_function	calcium ion binding
G	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA G 901

Chain	Residue
G	CGU26
G	CGU30

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA G 902

Chain	Residue
G	CGU8
G	CGU27
G	CGU30
G	HOH921

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 903

Chain	Residue
G	CGU30
G	HOH917
G	CGU8
G	CGU17
G	CGU27

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 904

Chain	Residue
G	TYR1
G	ASN2
G	CGU7
G	CGU8
G	CGU17
G	CGU27

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 905

Chain	Residue
G	TYR1
G	CGU7
G	CGU17
G	CGU21
G	HOH912

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA G 907

Chain	Residue
G	CGU15
G	CGU20

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site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 211

Chain	Residue
L	SER80
L	GLN109
L	TYR141
L	LYS167
L	HOH212

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Functional Information from PROSITE/UniProt

site_id	PS00011
Number of Residues	26
Details	GLA_1 Vitamin K-dependent carboxylation domain. EcmEEkCsfeearEvfentertte.FW

Chain	Residue	Details
G	CGU17-TRP42

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14722079, ECO:0007744|PDB:1NL0

Chain	Residue	Details
G	TYR1
G	ASN2

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: via 4-carboxyglutamate => ECO:0000305|PubMed:14722079, ECO:0007744|PDB:1NL0

Chain	Residue	Details
G	CGU7
G	CGU8
G	CGU17
G	CGU21
G	CGU27

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: via 4-carboxyglutamate => ECO:0000250|UniProtKB:P00741

Chain	Residue	Details
G	CGU15
G	CGU20
G	CGU26
G	CGU30
G	CGU36
G	CGU40

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: 4-carboxyglutamate => ECO:0000250|UniProtKB:P00741, ECO:0000255|PROSITE-ProRule:PRU00463

Chain	Residue	Details
G	CGU7
G	CGU33
G	CGU36
G	CGU40
G	CGU8
G	CGU15
G	CGU17
G	CGU20
G	CGU21
G	CGU26
G	CGU27
G	CGU30

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:25456591

Chain	Residue	Details
G	THR39

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