1JOU
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E (A, C, E) | Thrombin, light chain | polymer | 49 | 5641.2 | 3 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | COAGULATION FACTOR II |
| 2 | B, D, F (B, D, F) | Thrombin, heavy chain | polymer | 259 | 29764.2 | 3 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | COAGULATION FACTOR II |
| 3 | G, Q (B, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | H, O, R (B, D, F) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | I, J, K, L (B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | M, N, P, S, T (B, D, F) | ACETIC ACID | non-polymer | 60.1 | 5 | Chemie (ACY) | |||
| 7 | U, V, W, X, Y... (A, B, C, D, E...) | water | water | 18.0 | 372 | Chemie (HOH) |
Sequence modifications
B, D, F: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 106216.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1180.0 | |
| All* | Total formula weight | 107396.2 |
