1H2T
Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | 80 KDA NUCLEAR CAP BINDING PROTEIN | polymer | 723 | 83835.2 | 1 | UniProt (Q09161) Pfam (PF02854) Pfam (PF09088) Pfam (PF09090) | HOMO SAPIENS (HUMAN) | NCBP 80 KDA SUBUNIT, CBP80 |
| 2 | B (Z) | 20 KDA NUCLEAR CAP BINDING PROTEIN | polymer | 156 | 18028.1 | 1 | UniProt (P52298) Pfam (PF00076) | HOMO SAPIENS (HUMAN) | CBP20, NCBP 20 KDA SUBUNIT, NCBP INTERACTING PROTEIN 1, NIP1 |
| 3 | C (Z) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 4 | D (Z) | 7N-METHYL-8-HYDROGUANOSINE-5'-MONOPHOSPHATE | non-polymer | 379.3 | 1 | Chemie (7MG) | |||
| 5 | E, F (C, Z) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
C: 20 - 652 (UniProt: Q09161)
C: 702 - 790 (UniProt: Q09161)
C: 653 - 653 (PDB: 1H2T)
| PDB | External Database | Details |
|---|---|---|
| Ser 479 | Ala 479 | engineered mutation |
C: 653 - 653 (PDB: 1H2T)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 101863.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 822.5 | |
| All* | Total formula weight | 102685.8 |
