1G9M

HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (G)	ENVELOPE GLYCOPROTEIN GP120	polymer	321	35429.1	1	UniProt (P04578) Pfam (PF00516)	Human immunodeficiency virus 1
2	B (C)	T-CELL SURFACE GLYCOPROTEIN CD4	polymer	185	20503.3	1	UniProt (P01730) Pfam (PF00047) Pfam (PF05790)	Homo sapiens (human)
3	C (L)	ANTIBODY 17B, LIGHT CHAIN	polymer	214	23440.0	1		Homo sapiens (human)
4	D (H)	ANTIBODY 17B, HEAVY CHAIN	polymer	229	24525.6	1		Homo sapiens (human)
5	E, F (A, B)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	2	In PDB GlyTouCan (G86851RC)
6	G, H, I, J, K... (G)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	12	Chemie (NAG)
7	S (G)	ISOPROPYL ALCOHOL	non-polymer		60.1	1	Chemie (IPA)
8	T, U, V, W (G, C, L, H)	water	water		18.0	953	Chemie (HOH)

Sequence modifications

G: 83 - 127 (UniProt: P04578)

PDB	External Database	Details
Gly 79	-	cloning artifact
Ala 80	-	cloning artifact
Arg 81	-	cloning artifact
Ser 82	-	cloning artifact

G: 195 - 297 (UniProt: P04578)

PDB	External Database	Details
Gly 128	-	SEE REMARK 999
Ala 129	-	SEE REMARK 999
Gly 194	-	SEE REMARK 999

G: 330 - 492 (UniProt: P04578)

PDB	External Database	Details
Gly 298	-	SEE REMARK 999
Ala 299	-	SEE REMARK 999
Gly 329	-	SEE REMARK 999

C: 1 - 185 (UniProt: P01730)

PDB	External Database	Details
Asn 184	Ser 209	engineered mutation
Thr 185	Ile 210	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	103897.9
Branched	Number of molecules	2
	Total formula weight	734.7
Non-Polymers*	Number of molecules	13
	Total formula weight	2714.6
All*	Total formula weight	107347.2

*Water molecules are not included.