1C3R

CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	polymer	375	42701.6	2	UniProt (O67135) Pfam (PF00850)	Aquifex aeolicus
2	C, E (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, F (A, B)	TRICHOSTATIN A	non-polymer		302.4	2	Chemie (TSN)
4	G, H (A, B)	water	water		18.0	456	Chemie (HOH)

Sequence modifications

A, B: 1 - 375 (UniProt: O67135)

PDB	External Database	Details
Lys 35	Leu 35	conflict
Ser 75	Cys 75	engineered mutation
Ser 77	Cys 77	engineered mutation
Asn 146	Asp 146	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85403.3
Non-Polymers*	Number of molecules	4
	Total formula weight	735.6
All*	Total formula weight	86138.8

*Water molecules are not included.