1AXI
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GROWTH HORMONE | polymer | 191 | 22230.1 | 1 | UniProt (P01241) Pfam (PF00103) In PDB | Homo sapiens (human) | HGH |
2 | B | GROWTH HORMONE RECEPTOR | polymer | 236 | 27023.3 | 1 | UniProt (P10912) Pfam (PF09067) Pfam (PF00041) In PDB | Homo sapiens (human) | HGHBP |
3 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A: 1 - 191 (UniProt: P01241)
B: 1 - 236 (UniProt: P10912)
PDB | External Database | Details |
---|---|---|
Arg 120 | Gly 146 | engineered mutation |
Thr 129 | Glu 155 | conflict |
Arg 168 | Lys 194 | engineered mutation |
Thr 171 | Asp 197 | engineered mutation |
Tyr 172 | Lys 198 | engineered mutation |
Ala 174 | Glu 200 | engineered mutation |
Tyr 176 | Phe 202 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 31 | Lys 49 | conflict |
Glu 61 | Leu 79 | conflict |
Ala 104 | Trp 122 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 49253.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 96.1 | |
All* | Total formula weight | 49349.4 |