1AXI
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GROWTH HORMONE | polymer | 191 | 22230.1 | 1 | UniProt (P01241) Pfam (PF00103) | Homo sapiens (human) | HGH |
| 2 | B (B) | GROWTH HORMONE RECEPTOR | polymer | 236 | 27023.3 | 1 | UniProt (P10912) Pfam (PF09067) Pfam (PF00041) | Homo sapiens (human) | HGHBP |
| 3 | C (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 382 | Chemie (HOH) |
Sequence modifications
A: 1 - 191 (UniProt: P01241)
B: 1 - 236 (UniProt: P10912)
| PDB | External Database | Details |
|---|---|---|
| Arg 120 | Gly 146 | engineered mutation |
| Thr 129 | Glu 155 | conflict |
| Arg 168 | Lys 194 | engineered mutation |
| Thr 171 | Asp 197 | engineered mutation |
| Tyr 172 | Lys 198 | engineered mutation |
| Ala 174 | Glu 200 | engineered mutation |
| Tyr 176 | Phe 202 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 31 | Lys 49 | conflict |
| Glu 61 | Leu 79 | conflict |
| Ala 104 | Trp 122 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49253.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 49349.4 |
