1AXI
STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002092 | biological_process | positive regulation of receptor internalization |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005131 | molecular_function | growth hormone receptor binding |
| A | 0005148 | molecular_function | prolactin receptor binding |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007259 | biological_process | cell surface receptor signaling pathway via JAK-STAT |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0010828 | biological_process | positive regulation of D-glucose transmembrane transport |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0031904 | cellular_component | endosome lumen |
| A | 0031982 | cellular_component | vesicle |
| A | 0032355 | biological_process | response to estradiol |
| A | 0040018 | biological_process | positive regulation of multicellular organism growth |
| A | 0043410 | biological_process | positive regulation of MAPK cascade |
| A | 0043568 | biological_process | positive regulation of insulin-like growth factor receptor signaling pathway |
| A | 0046427 | biological_process | positive regulation of receptor signaling pathway via JAK-STAT |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048513 | biological_process | animal organ development |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0060396 | biological_process | growth hormone receptor signaling pathway |
| A | 0060397 | biological_process | growth hormone receptor signaling pathway via JAK-STAT |
| A | 0070186 | molecular_function | growth hormone activity |
| A | 0070195 | cellular_component | growth hormone receptor complex |
| A | 0070977 | biological_process | bone maturation |
| A | 0097696 | biological_process | cell surface receptor signaling pathway via STAT |
| B | 0004896 | molecular_function | cytokine receptor activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 237 |
| Chain | Residue |
| B | GLY148 |
| B | ILE149 |
| B | HIS150 |
| B | HOH456 |
Functional Information from PROSITE/UniProt
| site_id | PS00266 |
| Number of Residues | 34 |
| Details | SOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CfSesIpTPsnreeTqqksnleLlrisllLiqSW |
| Chain | Residue | Details |
| A | CYS53-TRP86 |
| site_id | PS01352 |
| Number of Residues | 79 |
| Details | HEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. IqVrWeaprnadiqkgwmvleYELqykevnetkwkmmdpilttsvpvys..LkvdkeyevrvRsKqrnsgn...YgeFsevlyV |
| Chain | Residue | Details |
| B | ILE153-VAL231 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14997482","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Deamidated glutamine; by deterioration","evidences":[{"source":"PubMed","id":"7028740","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 103 |
| Details | Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Motif: {"description":"WSXWS motif","evidences":[{"source":"PubMed","id":"14678285","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
