1KKQ
Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR | polymer | 269 | 30442.6 | 4 | UniProt (Q07869) Pfam (PF00104) | Homo sapiens (human) | PPAR-alpha ligand-binding domain |
| 2 | E, F, G, H (E, F, G, H) | NUCLEAR RECEPTOR CO-REPRESSOR 2 | polymer | 19 | 2240.7 | 4 | UniProt (Q9Y618) | nuclear corepressor SMRT C-terminal receptor interacting motif | |
| 3 | I, J, K, L (A, B, C, D) | N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE | non-polymer | 619.7 | 4 | Chemie (471) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 330 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 130733.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2478.7 | |
| All* | Total formula weight | 133211.7 |
