12FH

Structure of eIF2B bound to a activator

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Isoform 2 of Translation initiation factor eIF2B subunit delta	polymer	542	59649.2	2	UniProt (Q9UI10) Pfam (PF01008)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit delta
2	C, D (C, D)	Translation initiation factor eIF2B subunit beta	polymer	366	40998.4	2	UniProt (P49770) Pfam (PF01008)	Homo sapiens (human)	S20I15,S20III15,eIF2B GDP-GTP exchange factor subunit beta
3	E (F)	unidentified protein fragment	polymer	16	1379.7	1		Homo sapiens (human)
4	F, G (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)	Homo sapiens (human)
5	H (D)	N,N'-[(1S,2S,4R)-2-hydroxybicyclo[2.2.2]octane-1,4-diyl]bis[2-(4-chloro-3-fluorophenoxy)acetamide]	non-polymer		529.4	1	Chemie (A1DBY)
6	I, J (A, D)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

C, D: 1 - 351 (UniProt: P49770)

PDB	External Database	Details
Asp -14	-	expression tag
Tyr -13	-	expression tag
Lys -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	202675.0
Non-Polymers*	Number of molecules	3
	Total formula weight	721.5
All*	Total formula weight	203396.5

*Water molecules are not included.