12FH

Structure of eIF2B bound to a activator

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001541	biological_process	ovarian follicle development
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0006413	biological_process	translational initiation
A	0006417	biological_process	regulation of translation
A	0007417	biological_process	central nervous system development
A	0009408	biological_process	response to heat
A	0009749	biological_process	response to glucose
A	0014003	biological_process	oligodendrocyte development
A	0031369	molecular_function	translation initiation factor binding
A	0042552	biological_process	myelination
A	0043434	biological_process	response to peptide hormone
A	0045948	biological_process	positive regulation of translational initiation
A	0048513	biological_process	animal organ development
A	0050852	biological_process	T cell receptor signaling pathway
B	0001541	biological_process	ovarian follicle development
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0006413	biological_process	translational initiation
B	0006417	biological_process	regulation of translation
B	0007417	biological_process	central nervous system development
B	0009408	biological_process	response to heat
B	0009749	biological_process	response to glucose
B	0014003	biological_process	oligodendrocyte development
B	0031369	molecular_function	translation initiation factor binding
B	0042552	biological_process	myelination
B	0043434	biological_process	response to peptide hormone
B	0045948	biological_process	positive regulation of translational initiation
B	0048513	biological_process	animal organ development
B	0050852	biological_process	T cell receptor signaling pathway
C	0001541	biological_process	ovarian follicle development
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0006413	biological_process	translational initiation
C	0006446	biological_process	regulation of translational initiation
C	0007417	biological_process	central nervous system development
C	0009408	biological_process	response to heat
C	0009749	biological_process	response to glucose
C	0014003	biological_process	oligodendrocyte development
C	0042552	biological_process	myelination
C	0043434	biological_process	response to peptide hormone
C	0045948	biological_process	positive regulation of translational initiation
C	0048513	biological_process	animal organ development
C	0050852	biological_process	T cell receptor signaling pathway
D	0001541	biological_process	ovarian follicle development
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0006413	biological_process	translational initiation
D	0006446	biological_process	regulation of translational initiation
D	0007417	biological_process	central nervous system development
D	0009408	biological_process	response to heat
D	0009749	biological_process	response to glucose
D	0014003	biological_process	oligodendrocyte development
D	0042552	biological_process	myelination
D	0043434	biological_process	response to peptide hormone
D	0045948	biological_process	positive regulation of translational initiation
D	0048513	biological_process	animal organ development
D	0050852	biological_process	T cell receptor signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"May bind the chemical integrated stress response (ISR) inhibitor ISRIB","evidences":[{"source":"PubMed","id":"25858979","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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