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8WST
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BU of 8wst by Molmil
Cryo-EM structure of Melanin-Concentrating Hormone Receptor 2 with MCH
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha-1, ...
Authors:Zhao, L, He, Q, Yuan, Q, Gu, Y, Shan, H, Hu, W, Wu, K, Xu, H.E, Zhang, Y, Wu, C.
Deposit date:2023-10-17
Release date:2024-06-19
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors.
Cell Discov, 10, 2024
8WKZ
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BU of 8wkz by Molmil
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31
Descriptor: CALCIUM ION, Melanocortin receptor 4, OLEIC ACID, ...
Authors:Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S.
Deposit date:2023-09-28
Release date:2024-08-07
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J.Med.Chem., 67, 2024
8WKY
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BU of 8wky by Molmil
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S25
Descriptor: CALCIUM ION, Melanocortin receptor 4, N-(2-aminoethyl)-5-(2-{[4-(morpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)pyridine-3-carboxamide, ...
Authors:Gimenez, L.E, Martin, C, Yu, J, Hollanders, C, Hernandez, C, Dahir, N.S, Wu, Y, Yao, D, Han, G.W, Wu, L, Poorten, O.V, Lamouroux, A, Mannes, M, Tourwe, D, Zhao, S, Stevens, R.C, Cone, R.D, Ballet, S.
Deposit date:2023-09-28
Release date:2024-08-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.
J.Med.Chem., 67, 2024
8WGN
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BU of 8wgn by Molmil
Human dihydrofolate reductase (HsDHFR) complexed with NADPH and LA1
Descriptor: (3~{E})-3-[[2-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]oxypropoxy]phenyl]methylidene]oxolan-2-one, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Decharuangsilp, S, Arwon, U, Yuthavong, Y, Kamchonwongpaisan, S.
Deposit date:2023-09-22
Release date:2024-09-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors
Bioorg.Chem., 2024
8W1V
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BU of 8w1v by Molmil
The beta2 adrenergic receptor bound to a bitopic ligand
Descriptor: (2S)-1-[(3-{1-[4-(4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butyl]-1H-1,2,3-triazol-4-yl}propyl)amino]-3-(2-propylphenoxy)propan-2-ol, Beta-2 adrenergic receptor,Endolysin, Lauryl Maltose Neopentyl Glycol, ...
Authors:Gaiser, B, Danielsen, M, Xu, X, Jorgensen, K, Fronik, P, Marcher-Rorsted, E, Wrobe, T, Hirata, K, Liu, X, Mathiesen, J, Pedersen, D.
Deposit date:2024-02-19
Release date:2024-07-17
Last modified:2024-07-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bitopic Ligands Support the Presence of a Metastable Binding Site at the beta 2 Adrenergic Receptor.
J.Med.Chem., 67, 2024
8UO4
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BU of 8uo4 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class T)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UO3
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BU of 8uo3 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class S)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UO2
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BU of 8uo2 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class R)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UO1
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BU of 8uo1 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UO0
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BU of 8uo0 by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class P)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNZ
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BU of 8unz by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class O)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNY
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BU of 8uny by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNX
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BU of 8unx by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class M)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNW
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BU of 8unw by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class L)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNV
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BU of 8unv by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class K)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNU
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BU of 8unu by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class J)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNT
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BU of 8unt by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNS
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BU of 8uns by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNR
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BU of 8unr by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class G)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNQ
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BU of 8unq by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class F)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNP
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BU of 8unp by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class E)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNO
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BU of 8uno by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class D)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNN
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BU of 8unn by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNM
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BU of 8unm by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class B)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024
8UNL
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BU of 8unl by Molmil
CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class A)
Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Papasergi-Scott, M.M, Skiniotis, G.
Deposit date:2023-10-19
Release date:2024-03-06
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Time-resolved cryo-EM of G-protein activation by a GPCR.
Nature, 629, 2024

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PDB entries from 2024-09-18

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