1P57
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EXTRACELLULAR DOMAIN OF HUMAN HEPSIN
Descriptor:Serine protease hepsin, 2-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}BENZENOLATE
Authors:Somoza, J.R., Ho, J.D., Luong, C., Sprengeler, P.A., Mortara, K., Shrader, W.D., Sperandio, D., Chan, H., McGrath, M.E., Katz, B.A.
Deposit date:2003-04-25
Release date:2004-01-20
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Structure, 11, 2003
1O5E
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Serine protease hepsin, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1O5F
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Serine protease hepsin, 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1Z8G
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE TRANSMEMBRANE SERINE PROTEASE HEPSIN WITH COVALENTLY BOUND PREFERRED SUBSTRATE.
Descriptor:Serine protease hepsin, ACE-LYS-GLN-LEU-ARG-Chloromethylketone
Authors:Herter, S., Piper, D.E., Aaron, W., Gabriele, T., Cutler, G., Cao, P., Bhatt, A.S., Choe, Y., Craik, C.S., Walker, N., Meininger, D., Hoey, T., Austin, R.J.
Deposit date:2005-03-30
Release date:2005-05-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Biochem.J., 390, 2005
3T2N
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HUMAN HEPSIN PROTEASE IN COMPLEX WITH THE FAB FRAGMENT OF AN INHIBITORY ANTIBODY
Descriptor:Serine protease hepsin, Antibody, Fab fragment, ...
Authors:Koschubs, T., Dengl, S., Duerr, H., Kaluza, K., Georges, G., Hartl, C., Jennewein, S., Lanzendoerfer, M., Auer, J., Stern, A., Huang, K.-S., Kostrewa, D., Ries, S., Hansen, S., Kohnert, U., Cramer, P., Mundigl, O.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Allosteric antibody inhibition of human hepsin protease.
Biochem.J., 442, 2012
5CE1
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CRYSTAL STRUCTURE OF SERINE PROTEASE HEPSIN IN COMPLEX WITH INHIBITOR
Descriptor:Serine protease hepsin, 2-[6-(1-hydroxycyclohexyl)pyridin-2-yl]-1H-indole-5-carboximidamide
Authors:Rao, K.N., Anita, R.C., Sangeetha, R., Anirudha, L., Subramnay, H.
Deposit date:2015-07-06
Release date:2016-07-06
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Serine protease Hepsin in complex with Inhibitor
To Be Published
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