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9CC3
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BU of 9cc3 by Molmil
Human Mitochondrial LONP1 Stall State + casein
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Endogenous Co-purified substrate modeled as unknown residues, Lon protease homolog, ...
Authors:Mindrebo, J.T, Lander, G.C.
Deposit date:2024-06-20
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism.
Biorxiv, 2024
9CC0
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BU of 9cc0 by Molmil
Human Mitochondrial LONP1 Degrading Casein, ATP-bound closed form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bound substrate segment undergoing translocation and subsequent degradation, ...
Authors:Mindrebo, J.T, Lander, G.C.
Deposit date:2024-06-20
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structural and mechanistic studies on human LONP1 redefine the hand-over-hand translocation mechanism.
Biorxiv, 2024
8OVG
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BU of 8ovg by Molmil
Human Mitochondrial Lon Y186E Mutant ADP Bound
Descriptor: Lon protease homolog, mitochondrial
Authors:Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E.
Deposit date:2023-04-26
Release date:2024-05-08
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (8.47 Å)
Cite:Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
Sci Rep, 14, 2024
8OVF
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BU of 8ovf by Molmil
Human Mitochondrial Lon Y186F Mutant ADP Bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial
Authors:Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E.
Deposit date:2023-04-26
Release date:2024-05-08
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (7.23 Å)
Cite:Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
Sci Rep, 14, 2024
8OM7
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BU of 8om7 by Molmil
Human Mitochondrial Lon Y186E Mutant ADP Bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial
Authors:Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E.
Deposit date:2023-03-31
Release date:2024-04-10
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.74 Å)
Cite:Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
Sci Rep, 14, 2024
8OKA
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BU of 8oka by Molmil
Human Mitochondrial Lon Y394F Mutant ADP Bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial
Authors:Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E.
Deposit date:2023-03-28
Release date:2024-04-10
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.89 Å)
Cite:Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
Sci Rep, 14, 2024
8OJL
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BU of 8ojl by Molmil
Human Mitochondrial Lon Y394E Mutant ADP Bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial
Authors:Kereiche, S, Bauer, J.A, Matyas, P, Novacek, J, Kutejova, E.
Deposit date:2023-03-24
Release date:2024-04-03
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
Sci Rep, 14, 2024
8K97
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BU of 8k97 by Molmil
CryoEM structure of LonC protease hexamer with Bortezomib
Descriptor: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K96
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BU of 8k96 by Molmil
CryoEM structure of LonC protease hepatmer with Bortezomib
Descriptor: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PHOSPHATE ION, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K95
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BU of 8k95 by Molmil
CryoEM structure of LonC protease open Hexamer, AGS
Descriptor: Monothiophosphate, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K94
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BU of 8k94 by Molmil
CryoEM structure of LonC protease S582A open pentamer with lysozyme
Descriptor: Endopeptidase La, Monothiophosphate
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K93
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BU of 8k93 by Molmil
CryoEM structure of LonC protease S582A open hexamer with lysozyme
Descriptor: Endopeptidase La, Monothiophosphate
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K92
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BU of 8k92 by Molmil
CryoEM structure of LonC S582A hexamer with Lysozyme
Descriptor: Endopeptidase La, Monothiophosphate
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K91
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BU of 8k91 by Molmil
CryoEM structure of LonC S582A hepatmer with Lysozyme
Descriptor: Endopeptidase La, Monothiophosphate
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K90
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BU of 8k90 by Molmil
CryoEM structure of LonC protease open pentamer in presence of AGS
Descriptor: Monothiophosphate, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K8Z
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BU of 8k8z by Molmil
CryoEM structure of LonC protease hexamer in presence of AGS
Descriptor: Monothiophosphate, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K8Y
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BU of 8k8y by Molmil
CryoEM structure of LonC heptamer in presence of AGS
Descriptor: Monothiophosphate, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K8X
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BU of 8k8x by Molmil
CryoEM of LonC open pentamer, apo state
Descriptor: endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K8W
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BU of 8k8w by Molmil
CryoEM structure of LonC protease open hexamer, apo state
Descriptor: endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K8V
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BU of 8k8v by Molmil
CryoEM structure of LonC protease hepatmer, apo state
Descriptor: PHOSPHATE ION, endopeptidase La
Authors:Li, M, Hsieh, K, Liu, H, Zhang, S, Gao, Y, Gong, Q, Zhang, K, Chang, C, Li, S.
Deposit date:2023-07-31
Release date:2024-08-07
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis
Fundam Res, 2024
8K3Y
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BU of 8k3y by Molmil
The "5+1" heteromeric structure of Lon protease consisting of a spiral pentamer with Y224S mutation and an N-terminal-truncated monomeric E613K mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Lon protease
Authors:Li, S, Hsieh, K.Y, Kuo, C.I, Zhang, K, Chang, C.I.
Deposit date:2023-07-17
Release date:2023-10-25
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (4.42 Å)
Cite:A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine.
Nat Commun, 14, 2023
8EMH
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BU of 8emh by Molmil
CryoEM characterization of a unique AAA+ BrxL phage restriction factor
Descriptor: DNA (63-MER), DNA (64-MER), Protease Lon-related BREX system protein BrxL
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2022-09-27
Release date:2023-02-01
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor.
Nucleic Acids Res., 51, 2023
8EMC
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BU of 8emc by Molmil
CryoEM characterization of BrxL -- a unique AAA+ phage restriction Factor.
Descriptor: Protease Lon-related BREX system protein BrxL
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2022-09-27
Release date:2023-02-01
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor.
Nucleic Acids Res., 51, 2023
8EIL
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BU of 8eil by Molmil
C-Terminal Domain of BrxL from Acinetobacter BREX type I phage restriction system
Descriptor: MALONIC ACID, Protease Lon-related BREX system protein BrxL, SUCCINIC ACID
Authors:Doyle, L.A, Stoddard, B.L, Kaiser, B.
Deposit date:2022-09-15
Release date:2023-02-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor.
Nucleic Acids Res., 51, 2023
8DVH
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BU of 8dvh by Molmil
Crystal structure of ATP-dependent Lon protease from Bacillus subtillis (BsLonBA)
Descriptor: Lon protease 2, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, SODIUM ION
Authors:Sekula, B, Li, M, Gustchina, A, Wlodawer, A.
Deposit date:2022-07-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases.
Int J Mol Sci, 23, 2022

 

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