6FI7
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E.COLI SIGMA FACTOR S (RPOS) REGION 4
Descriptor:RNA polymerase sigma factor RpoS
Authors:Liu, B., Matthews, S.J.
Deposit date:2018-01-17
Release date:2018-06-06
Last modified:2018-06-13
Method:SOLUTION NMR
Cite:T7 phage factor required for managing RpoS inEscherichia coli.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6FBV
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SINGLE PARTICLE CRYO EM STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RNA POLYMERASE IN COMPLEX WITH FIDAXOMICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Das, K., Lin, W., Ebright, E.
Deposit date:2017-12-19
Release date:2018-02-28
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
6DCF
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH RIFAMPICIN-RESISTANT RNA POLYMERASE AND BOUND TO KANGLEMYCIN A
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-05-06
Release date:2018-09-05
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A
To Be Published
6CUX
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ESCHERICHIA COLI RPOB S531L MUTANT RNA POLYMERASE HOLOENZYME IN COMPLEX WITH KANGLEMYCIN A
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V., Murakami, K.S.
Deposit date:2018-03-26
Release date:2018-07-25
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (4.104 Å)
Cite:Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
6CUU
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THERMUS THERMOPHILES RNA POLYMERASE IN COMPLEX WITH PROMOTER DNA AND ANTIBIOTIC KANGLEMYCIN A
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Molodtsov, V., Murakami, K.S.
Deposit date:2018-03-26
Release date:2018-07-25
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
6CCV
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH INHIBITOR RIFAMPICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with inhibitor Rifampicin
To Be Published
6CCE
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CRYSTAL STRUCTURE OF A MYCOBACTERIUM SMEGMATIS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX WITH INHIBITOR KANGLEMYCIN A
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Lilic, M., Darst, S.A., Campbell, E.A.
Deposit date:2018-02-07
Release date:2018-08-15
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Kanglemycin A
To Be Published
6CA0
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CRYO-EM STRUCTURE OF E. COLI RNAP SIGMA70 OPEN COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Narayanan, A., Vago, F., Li, K., Qayyum, M.Z., Yernool, D., Jiang, W., Murakami, K.S.
Deposit date:2018-01-29
Release date:2018-02-28
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (5.75 Å)
Cite:Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018
6C9Y
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CRYO-EM STRUCTURE OF E. COLI RNAP SIGMA70 HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Narayanan, A., Vago, F., Li, K., Qayyum, M.Z., Yenool, D., Jiang, W., Murakami, K.S.
Deposit date:2018-01-29
Release date:2018-02-28
Last modified:2018-05-23
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation.
J. Biol. Chem., 293, 2018
6C06
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA/FIDAXOMICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C05
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MYCOBACTERIUM TUBERCULOSIS RNAP HOLO/RBPA IN RELAXED STATE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (5.15 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6C04
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MTB RNAP HOLO/RBPA/DOUBLE FORK DNA -CLOSED CLAMP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J., Lilic, M.
Deposit date:2017-12-27
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6BZO
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MTB RNAP HOLO/RBPA/FIDAXOMICIN/UPSTREAM FORK DNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2017-12-25
Release date:2018-03-28
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts.
Elife, 7, 2018
6BYU
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE (RPOB-H526Y) AND PPAPP COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S., Molodtsov, V.
Deposit date:2017-12-21
Release date:2018-01-17
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure-function comparisons of (p)ppApp vs (p)ppGpp for Escherichia coli RNA polymerase binding sites and for rrnB P1 promoter regulatory responses in vitro.
Biochim. Biophys. Acta, 1861, 2018
6B6H
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THE CRYO-EM STRUCTURE OF A BACTERIAL CLASS I TRANSCRIPTION ACTIVATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Hong, C., Huang, R., Yu, Z., Steitz, T.A.
Deposit date:2017-10-02
Release date:2017-11-15
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of bacterial transcription activation.
Science, 358, 2017
5XJ0
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T. THERMOPHILUS RNA POLYMERASE HOLOENZYME BOUND WITH GP39 AND GP76
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Ooi, W.Y., Murayama, Y., Mekler, V., Minakhin, L., Severinov, K., Yokoyama, S., Sekine, S.
Deposit date:2017-04-28
Release date:2017-12-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (4.004 Å)
Cite:A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation
Nucleic Acids Res., 46, 2018
5X22
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX WITH GPA AND CMPCPP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.
Deposit date:2017-01-29
Release date:2017-07-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Cell, 169, 2017
5X21
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX WITH GPA AND PSEUDOURIDIMYCIN (PUM)
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.
Deposit date:2017-01-29
Release date:2017-07-05
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.323 Å)
Cite:Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.
Cell, 169, 2017
5W1T
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE AND DKSA COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S., Molodtsov, V.
Deposit date:2017-06-04
Release date:2017-06-14
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
Mol. Cell, 69, 2018
5W1S
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE AND TRAR COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S., Molodtsov, V.
Deposit date:2017-06-04
Release date:2017-06-14
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3.805 Å)
Cite:Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
Mol. Cell, 69, 2018
5VT0
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ESCHERICHIA COLI 6S RNA DERIVATIVE IN COMPLEX WITH ESCHERICHIA COLI RNA POLYMERASE SIGMA70-HOLOENZYME
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Chen, J., Darst, S.A.
Deposit date:2017-05-15
Release date:2017-11-01
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase.
Mol. Cell, 68, 2017
5VSW
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X-RAY CRYSTAL STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE AND DKSA/PPGPP COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S., Molodtsov, V.
Deposit date:2017-05-12
Release date:2017-06-14
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (4.295 Å)
Cite:Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
Mol. Cell, 69, 2018
5VOI
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X-RAY CRYSTAL STRUCTURE OF BACTERIAL RNA POLYMERASE AND PYRG PROMOTER COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S., Shin, Y., Turnbough Jr, C.L., Molodtsov, V.
Deposit date:2017-05-02
Release date:2017-05-24
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VO8
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X-RAY CRYSTAL STRUCTURE OF A BACTERIAL REITERATIVE TRANSCRIPTION COMPLEX OF PYRG PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murakami, K.S., Shin, Y., Turnbough Jr, C.L., Molodtsov, V.
Deposit date:2017-05-02
Release date:2017-05-24
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VI8
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STRUCTURE OF A MYCOBACTERIUM SMEGMATIS TRANSCRIPTION INITIATION COMPLEX WITH AN UPSTREAM-FORK PROMOTER FRAGMENT
Descriptor:RNA polymerase-binding protein RbpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
Authors:Hubin, E.A., Campbell, E.A., Darst, S.A.
Deposit date:2017-04-14
Release date:2017-04-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.
Elife, 6, 2017
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