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9BK2
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BU of 9bk2 by Molmil
Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form)
Descriptor: (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, DIMETHYL SULFOXIDE, L-lactate dehydrogenase A chain, ...
Authors:Lovell, S, Cooper, A, Battaile, K.P, Sharma, H.
Deposit date:2024-04-26
Release date:2024-07-10
Last modified:2024-09-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
8RS5
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BU of 8rs5 by Molmil
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 4
Descriptor: CHLORIDE ION, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Coquille, S, Engilberge, S, Madern, D.
Deposit date:2024-01-24
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To Be Published
8RWL
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BU of 8rwl by Molmil
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 1
Descriptor: CHLORIDE ION, GLYCEROL, Malate dehydrogenase, ...
Authors:Coquille, S, Roche, J, Engilberge, S, Girard, E, Madern, D.
Deposit date:2024-02-05
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To Be Published
9BK3
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BU of 9bk3 by Molmil
Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (R-enantiomer, orthorhombic P form)
Descriptor: (2R)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, CHLORIDE ION, L-lactate dehydrogenase A chain, ...
Authors:Lovell, S, Cooper, A, Battaile, K.P, Sharma, H.
Deposit date:2024-04-26
Release date:2024-07-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
9END
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BU of 9end by Molmil
Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 3
Descriptor: CHLORIDE ION, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Coquille, S, Roche, J, Girard, E, Madern, D.
Deposit date:2024-03-12
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To be published
9FEE
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BU of 9fee by Molmil
Cryo-EM structure of Trypanosoma cruzi glycosomal malate dehydrogenase
Descriptor: malate dehydrogenase
Authors:Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2024-05-19
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Cryo-EM structure of Trypanosoma cruzi glycosomal malate dehydrogenase
To Be Published
9FEF
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BU of 9fef by Molmil
Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex
Descriptor: Peroxisome targeting signal 1 receptor, malate dehydrogenase
Authors:Lipinski, O, Sonani, R.R, Blat, A, Jemiola-Rzeminska, M, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2024-05-19
Release date:2024-05-29
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Cryo-EM structure of Trypanosoma cruzi (MDH)4-PEX5 complex
To Be Published
8GH3
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BU of 8gh3 by Molmil
Structure of Trypanosoma (MDH)4-(Pex5)2, distal conformation
Descriptor: Peroxisome targeting signal 1 receptor, malate dehydrogenase
Authors:Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2023-03-09
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Structure of Trypanosoma (MDH)4-(Pex5)2, distal conformation
To Be Published
8GH2
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BU of 8gh2 by Molmil
Structure of Trypanosoma (MDH)4-(Pex5)2, close conformation
Descriptor: Peroxisome targeting signal 1 receptor, malate dehydrogenase
Authors:Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2023-03-09
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure of Trypanosoma (MDH)4-(Pex5)2, close conformation
To Be Published
8GI0
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BU of 8gi0 by Molmil
Structure of Trypanosoma docking complex
Descriptor: Peroxisomal membrane protein PEX14, Peroxisome targeting signal 1 receptor, malate dehydrogenase
Authors:Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2023-03-13
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of Trypanosoma docking complex
To Be Published
8GGH
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BU of 8ggh by Molmil
Structure of Trypanosoma (MDH)4-PEX5, distal conformation
Descriptor: Peroxisome targeting signal 1 receptor, malate dehydrogenase
Authors:Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2023-03-08
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Structure of Trypanosoma (MDH)4-PEX5, distal conformation
To Be Published
8GGD
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BU of 8ggd by Molmil
Structure of Trypanosoma (MDH)4-Pex5, close conformation
Descriptor: Peroxisome targeting signal 1 receptor, malate dehydrogenase
Authors:Sonani, R.R, Artur, B, Jemiola-Rzeminska, M, Lipinski, O, Patel, S.N, Sood, T, Dubin, G.
Deposit date:2023-03-08
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Structure of Trypanosoma (MDH)4-Pex5, close conformation
To Be Published
8FW6
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BU of 8fw6 by Molmil
Human Lactate Dehydrogenase A in Complex with Inhibitor CHK-336
Descriptor: (2P)-2-{5-(cyclopropylmethyl)-3-(4-fluorophenyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Lowther, W.T, Gumpena, R.
Deposit date:2023-01-20
Release date:2024-01-24
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Human Lactate Dehydrogenase A in complex with inhibitor CHK-336
To Be Published
8J5D
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BU of 8j5d by Molmil
Cryo-EM structure of starch degradation complex of BAM1-LSF1-MDH
Descriptor: Beta-amylase 1, chloroplastic, Malate dehydrogenase, ...
Authors:Guan, Z.Y, Liu, J, Yan, J.J.
Deposit date:2023-04-21
Release date:2024-01-10
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The LIKE SEX FOUR 1-malate dehydrogenase complex functions as a scaffold to recruit beta-amylase to promote starch degradation.
Plant Cell, 36, 2023
8Q3C
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BU of 8q3c by Molmil
Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant
Descriptor: CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ...
Authors:Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D.
Deposit date:2023-08-03
Release date:2023-11-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases.
J.Struct.Biol., 215, 2023
7QOZ
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BU of 7qoz by Molmil
Crystal structure of NAD-bound glycosomal malate dehydrogenase from Trypanosoma cruzi
Descriptor: GLYCEROL, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Sonani, R.R, Dubin, G.
Deposit date:2021-12-30
Release date:2023-07-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of NAD-bound glycosomal malate dehydrogenase from Trypanosoma cruzi
To Be Published
7XQN
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BU of 7xqn by Molmil
InDel-mutant malate dehydrogenase from E. coli
Descriptor: Malate dehydrogenase
Authors:Toledo-Patino, S, Laurino, P.
Deposit date:2022-05-08
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Insertions and deletions mediated functional divergence of Rossmann fold enzymes.
Proc.Natl.Acad.Sci.USA, 119, 2022
7X1L
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BU of 7x1l by Molmil
Malate dehydrogenase from Geobacillus stearothermophilus (gs-MDH) delta E311 mutant complexed with Nicotinamide Adenine Dinucleotide (NAD+)
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shimozawa, Y, Himiyama, T, Nakamura, T, Nishiya, Y.
Deposit date:2022-02-24
Release date:2022-10-19
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Reducing substrate inhibition of malate dehydrogenase from Geobacillus stearothermophilus by C-terminal truncation.
Protein Eng.Des.Sel., 35, 2022
8AB2
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BU of 8ab2 by Molmil
Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in its apo form.
Descriptor: 1,2-ETHANEDIOL, L-lactate dehydrogenase, TERBIUM(III) ION, ...
Authors:Robin, A.Y, Girard, E, Madern, D.
Deposit date:2022-07-04
Release date:2022-08-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery.
Mol.Biol.Evol., 40, 2023
8AB3
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BU of 8ab3 by Molmil
Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in complex with oxamate, NADH and FBP.
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,6-di-O-phosphono-beta-D-fructofuranose, L-lactate dehydrogenase, ...
Authors:Robin, A.Y, Girard, E, Madern, D.
Deposit date:2022-07-04
Release date:2022-07-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.616 Å)
Cite:Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery.
Mol.Biol.Evol., 40, 2023
7P4G
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BU of 7p4g by Molmil
Rabbit Muscle L-lactate dehydrogenase in complex with citrate
Descriptor: CITRIC ACID, L-lactate dehydrogenase A chain
Authors:Iacovino, L.G, Binda, C, Hochkoeppler, A.
Deposit date:2021-07-11
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme.
Biochimie, 199, 2022
7EPM
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BU of 7epm by Molmil
human LDHC complexed with NAD+ and ethylamino acetic acid
Descriptor: 2-(ethylamino)-2-oxidanylidene-ethanoic acid, L-lactate dehydrogenase C chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Yu, Y, Chen, Q.
Deposit date:2021-04-27
Release date:2022-03-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Identification of human LDHC4 as a potential target for anticancer drug discovery.
Acta Pharm Sin B, 12, 2022
7F8D
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BU of 7f8d by Molmil
Malate Dehydrogenase from Geobacillus stearothermophilus (gs-MDH) G218Y mutant
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shimozawa, Y, Himiyama, T, Nakamura, T, Nishiya, Y.
Deposit date:2021-07-02
Release date:2022-02-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Increasing loop flexibility affords low-temperature adaptation of a moderate thermophilic malate dehydrogenase from Geobacillus stearothermophilus.
Protein Eng.Des.Sel., 34, 2021
7Q3X
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BU of 7q3x by Molmil
Crystal structure of Malate dehydrogenase from Haloarcula marismortui with Potassium and Chloride ions
Descriptor: CHLORIDE ION, Malate dehydrogenase, POTASSIUM ION
Authors:Bertrand, Q, Roche, J, Girard, E, Madern, D.
Deposit date:2021-10-29
Release date:2022-02-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Resurrection of Ancestral Malate Dehydrogenases Reveals the Evolutionary History of Haloarchaeal Proteins.
To Be Published
7NRZ
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BU of 7nrz by Molmil
Crystal structure of malate dehydrogenase from Trypanosoma cruzi
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Sonani, R.R, Kurpiewska, K, Lewinski, K, Dubin, G.
Deposit date:2021-03-04
Release date:2022-02-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Distinct sequence and structural feature of trypanosoma malate dehydrogenase.
Biochem.Biophys.Res.Commun., 557, 2021

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PDB entries from 2024-09-18

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