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2W20	Structure of the catalytic domain of the native NanA sialidase from Streptococcus pneumoniae Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, GLYCEROL, ... Authors: Xu, G, Andrew, P.W, Taylor, G.L. Deposit date: 2008-10-21 Release date: 2008-12-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Structure of the Catalytic Domain of Streptococcus Pneumoniae Sialidase Nana. Acta Crystallogr.,Sect.F, 64, 2008
4XJW	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with DMSO as the cryoprotectant Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... Authors: Brear, P. Deposit date: 2015-01-09 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.53 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
2JKB	Crystal structure of Streptococcus pneumoniae NanB in complex with 2, 7-anhydro-Neu5Ac Descriptor: 1,2-ETHANEDIOL, 2-ACETYLAMINO-7-(1,2-DIHYDROXY-ETHYL)-3-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCTANE-5-CARBOXYLIC ACID, SIALIDASE B Authors: Gut, H, King, S.J, Walsh, M.A. Deposit date: 2008-08-26 Release date: 2008-09-16 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Structural and Functional Studies of Streptococcus Pneumoniae Neuraminidase B: An Intramolecular Trans-Sialidase. FEBS Lett., 582, 2008
4XJZ	Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 7.4 in PBS with DMSO Descriptor: DIMETHYL SULFOXIDE, PHOSPHATE ION, Sialidase B Authors: Brear, P. Deposit date: 2015-01-09 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.56 Å) Cite: The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
3H73	Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA) in complex with DANA Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, Sialidase A Authors: Hsiao, Y.-S, Tong, L. Deposit date: 2009-04-24 Release date: 2009-05-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structures of respiratory pathogen neuraminidases Biochem.Biophys.Res.Commun., 380, 2009
3H72	Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA) in complex with NANA Descriptor: N-acetyl-alpha-neuraminic acid, Sialidase A Authors: Hsiao, Y.-S, Tong, L. Deposit date: 2009-04-24 Release date: 2009-05-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structures of respiratory pathogen neuraminidases Biochem.Biophys.Res.Commun., 380, 2009
3H71	Crystal structure of Streptococcus pneumoniae D39 neuraminidase A precursor (NanA) Descriptor: Sialidase A Authors: Hsiao, Y.-S, Tong, L. Deposit date: 2009-04-24 Release date: 2009-05-12 Last modified: 2019-09-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structures of respiratory pathogen neuraminidases Biochem.Biophys.Res.Commun., 380, 2009
2VW2	Crystal structure of the NanB sialidase from Streptococcus pneumoniae Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, SIALIDASE B Authors: Xu, G, Potter, J.A, Russell, R.J.M, Oggioni, M.R, Andrew, P.W, Taylor, G.L. Deposit date: 2008-06-13 Release date: 2008-06-24 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of the Nanb Sialidase from Streptococcus Pneumoniae J.Mol.Biol., 384, 2008
4XIO	Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD as the cryoprotectant Descriptor: Sialidase B Authors: Brear, P. Deposit date: 2015-01-07 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XE9	Crystal structure of the NanB sialidase from Streptococcus pneumoniae in complex with Optactin Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2014-12-23 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.84 Å) Cite: The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4FQ4	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Fluoro-3-methylbenzyl)ammonio]ethanesulfonate Descriptor: 2-[(4-fluoro-3-methylbenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-25 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.843 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FOY	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-(Benzylammonio)ethanesulfonate Descriptor: 2-(benzylamino)ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-21 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.843 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4XHB	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with pentanediol and CHES Descriptor: (1R,2S)-cyclopentane-1,2-diol, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Sialidase B Authors: Brear, P. Deposit date: 2015-01-05 Release date: 2016-01-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.88 Å) Cite: The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XIL	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with MPD as the cryoprotectant Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, Sialidase B Authors: Brear, P. Deposit date: 2015-01-07 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XIK	Crystal structure of NanB sialidase from streptococcus pneumoniae in complex with DMSO Descriptor: DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2015-01-07 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.91 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4FPH	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Fluorobenzyl)ammonio]ethanesulfonate Descriptor: 2-[(3-fluorobenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-22 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.938 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4XJU	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid Descriptor: (1R,2R,3R,4R,5R,7R)-2-(acetylamino)-7-[(1R)-1,2-dihydroxyethyl]-4-fluoro-3-hydroxy-6,8-dioxabicyclo[3.2.1]octane-5-carboxylic acid, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... Authors: Brear, P. Deposit date: 2015-01-09 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.94 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XMI	Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae Descriptor: DIMETHYL SULFOXIDE, PHOSPHATE ION, Sialidase B Authors: Brear, P. Deposit date: 2015-01-14 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.97 Å) Cite: The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4YZ1	Crystal Structure of Streptococcus pneumoniae NanC, apo structure. Descriptor: Putative neuraminidase, SULFATE ION Authors: Lukacik, P, Owen, D.O, Potter, J.A, Taylor, G.L, Walsh, M.A. Deposit date: 2015-03-24 Release date: 2015-09-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR. J.Biol.Chem., 290, 2015
4XJ9	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 5.0 in 50mM Sodium Acetate with DMSO as the cryoprotectant Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2015-01-08 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.98 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XJA	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, DIMETHYL SULFOXIDE, ... Authors: Brear, P. Deposit date: 2015-01-08 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.98 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4FPJ	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Methoxybenzyl)ammonio]ethanesulfonate Descriptor: 2-[(3-methoxybenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-22 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.981 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FOQ	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-aminoethanesulfonic acid Descriptor: 2-AMINOETHANESULFONIC ACID, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-21 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4YW2	Crystal Structure of Streptococcus pneumoniae NanC, complex 6'SL Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ... Authors: Owen, C.D, Lukacik, P, Potter, J.A, Walsh, M, Taylor, G.L. Deposit date: 2015-03-20 Release date: 2015-09-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR. J.Biol.Chem., 290, 2015
4YW3	Crystal Structure of Streptococcus pneumoniae NanC, complex with Neu5Ac and Neu5Ac2en following soaking with Neu5Ac2en Descriptor: 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL, N-acetyl-alpha-neuraminic acid, ... Authors: Owen, C.D, Lukacik, P, Potter, J.A, Walsh, M, Taylor, G.L. Deposit date: 2015-03-20 Release date: 2015-09-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR. J.Biol.Chem., 290, 2015

 

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