PDB: 75 resultsInfo pagesStatus searchChemie searchBIRD

---

6BCN	I-LtrI E184D bound to cognate substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (26-MER), Ribosomal protein 3/homing endonuclease-like fusion protein Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
6BCG	I-LtrI A28G bound to cognate substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (26-MER), Ribosomal protein 3/homing endonuclease-like fusion protein Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
6BD0	I-OnuI K227Y, D236A bound to cognate substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (25-MER), Ribosomal protein 3/homing endonuclease-like protein fusion Authors: Brown, C, Zhang, K, Laforet, M, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.45 Å) Cite: I-OnuI K227Y, D236A bound to cognate substrate (pre-cleavage complex) To Be Published
6BCF	I-LtrI G183A bound to cognate substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (26-MER), Ribosomal protein 3/homing endonuclease-like fusion protein Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
6BDB	I-OnuI K227Y, D236A bound to A3G substrate (pre-cleavage complex) Descriptor: DNA (26-MER), Ribosomal protein 3/homing endonuclease-like protein fusion Authors: Brown, C, Zhang, K, McMurrough, T.A, Laforet, M, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-22 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: I-OnuI K227Y, D236A bound to A3G substrate (pre-cleavage complex) To Be Published
6BCH	I-LtrI E29D bound to cognate substrate (nicked complex) Descriptor: DNA (26-MER), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(*TP*AP*GP*GP*AP*GP*CP*AP*TP*TP*T)-3'), ... Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: I-LtrI E29D bound to cognate substrate (nicked complex) To Be Published
6BCT	I-LtrI E184D bound to non-cognate C4 substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (26-MER), DNA (27-MER), ... Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
6BDA	Wild-type I-OnuI bound to A3G substrate (post-cleavage complex) Descriptor: Cleaved Cognate DNA strand, +11 sense, Cleaved cognate DNA strand, ... Authors: Brown, C, Zhang, K, Laforet, M, McMurrough, T, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-22 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Wild-type I-OnuI bound to A3G substrate (post-cleavage complex) To Be Published
6BCE	Wild-type I-LtrI bound to cognate substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
6BCI	Wild-type I-LtrI bound to non-cognate C4 substrate (pre-cleavage complex) Descriptor: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein Authors: Brown, C, Zhang, K, McMurrough, T.A, Gloor, G.B, Edgell, D.R, Junop, M. Deposit date: 2017-10-20 Release date: 2018-10-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Active site residue identity regulates cleavage preference of LAGLIDADG homing endonucleases. Nucleic Acids Res., 46, 2018
6FB1	Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Magnesium Descriptor: DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.024 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB8	Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with an altered version of its target DNA at 5NNN region in the presence of Magnesium Descriptor: DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*CP*GP*CP*AP*GP*TP*TP*TP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), DNA endonuclease I-CreI, ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB7	Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with its target DNA in the presence of Manganese Descriptor: DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), DNA endonuclease I-CreI, ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.689 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB6	Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with an altered version of its target DNA (Haemoglobin beta subunit gene) at 5NNN region in the presence of Manganese Descriptor: DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), DNA (5'-D(P*AP*CP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB9	Crystal Structure of the I-CreI Homing Endonuclease D75N variant in complex with an altered version of its target DNA at 5NNN region in the presence of Manganese Descriptor: DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3'), DNA (5'-D(*TP*CP*AP*AP*AP*AP*CP*TP*GP*CP*GP*TP*AP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3'), ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB5	Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with an altered version of its target DNA (Haemoglobin beta subunit gene) at 5NNN region in the presence of Magnesium Descriptor: ACETATE ION, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*GP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*GP*AP*CP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB0	Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Calcium Descriptor: ACETATE ION, CALCIUM ION, DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*CP*AP*GP*GP*AP*GP*TP*CP*AP*GP*A)-3'), ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
6FB2	Crystal Structure of a Tailored I-CreI Homing Endonuclease Protein (3115 variant) in complex with its target DNA (Haemoglobin beta subunit gene) in the presence of Manganese Descriptor: DNA (5'-D(*TP*CP*AP*GP*AP*CP*TP*TP*CP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*CP*TP*CP*CP*TP*GP*TP*GP*G)-3'), DNA (5'-D(P*AP*GP*AP*AP*GP*TP*CP*TP*GP*A)-3'), ... Authors: Molina, R, Prieto, J. Deposit date: 2017-12-18 Release date: 2018-07-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Understanding the indirect DNA read-out specificity of I-CreI Meganuclease. Sci Rep, 8, 2018
5GKK	Crystal structure of a homing endonuclease, I-TnaI Descriptor: Putative homing endonuclease Authors: Ren, J. Deposit date: 2016-07-04 Release date: 2017-07-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Crystal structure of a homing endonuclease, I-TnaI To Be Published
4Z20	Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTGT Central Four Descriptor: CALCIUM ION, DNA (26-MER), GLYCEROL, ... Authors: Hallinan, J.P, Stoddard, B.L. Deposit date: 2015-03-27 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4Z1Z	Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTCT Central Four Descriptor: CALCIUM ION, DNA (28-MER), GLYCEROL, ... Authors: Hallinan, J.P, Stoddard, B.L. Deposit date: 2015-03-27 Release date: 2016-03-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
5ESP	Crystal Structure of LAGLIDADG Meganuclease I-PanMI with coordinated Calcium ions Descriptor: CALCIUM ION, DNA (27-MER), GLYCEROL, ... Authors: Hallinan, J.P, Stoddard, B.L. Deposit date: 2015-11-16 Release date: 2016-03-30 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.995 Å) Cite: Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4YIT	Crystal Structure of LAGLIDADG Meganuclease I-AabMI Bound to Uncleaved DNA Descriptor: CALCIUM ION, DNA (25-MER), DNA (25MER), ... Authors: Hallinan, J.P, Stoddard, B.L. Deposit date: 2015-03-02 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.24 Å) Cite: Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4YIS	Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ... Authors: Hallinan, J.P, Kaiser, B.K, Stoddard, B.L. Deposit date: 2015-03-02 Release date: 2016-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.89 Å) Cite: Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
4YHX	Crystal Structure of LAGLIDADG Meganuclease I-GpeMI Bound to Uncleaved DNA Descriptor: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein Authors: Hallinan, J.P, Kaiser, B.K, Stoddard, B.L. Deposit date: 2015-02-27 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016

 

123>