1LDJ
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STRUCTURE OF THE CUL1-RBX1-SKP1-F BOXSKP2 SCF UBIQUITIN LIGASE COMPLEX
Descriptor:Cullin homolog 1, ring-box protein 1, ZINC ION
Authors:Zheng, N., Schulman, B.A., Song, L., Miller, J.J., Jeffrey, P.D., Wang, P., Chu, C., Koepp, D.M., Elledge, S.J., Pagano, M., Conaway, R.C., Conaway, J.W., Harper, J.W., Pavletich, N.P.
Deposit date:2002-04-08
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Nature, 416, 2002
1U6G
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CRYSTAL STRUCTURE OF THE CAND1-CUL1-ROC1 COMPLEX
Descriptor:Cullin homolog 1, RING-box protein 1, TIP120 protein, ...
Authors:Goldenberg, S.J., Shumway, S.D., Cascio, T.C., Garbutt, K.C., Liu, J., Xiong, Y., Zheng, N.
Deposit date:2004-07-29
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases
Cell(Cambridge,Mass.), 119, 2004
4A0K
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STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX
Descriptor:CULLIN-4A, E3 UBIQUITIN-PROTEIN LIGASE RBX1, DNA DAMAGE-BINDING PROTEIN 1, ...
Authors:Fischer, E.S., Scrima, A., Gut, H., Thoma, N.H.
Deposit date:2011-09-09
Release date:2011-12-14
Method:X-RAY DIFFRACTION (5.93 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
5N4W
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CRYSTAL STRUCTURE OF THE CUL2-RBX1-ELOBC-VHL UBIQUITIN LIGASE COMPLEX
Descriptor:Cullin-2, Von Hippel-Lindau disease tumor suppressor, E3 ubiquitin-protein ligase RBX1, ...
Authors:Cardote, T.A.F., Gadd, M.S., Ciulli, A.
Deposit date:2017-02-11
Release date:2017-06-07
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
Structure, 25, 2017
2HYE
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CRYSTAL STRUCTURE OF THE DDB1-CUL4A-RBX1-SV5V COMPLEX
Descriptor:DNA damage-binding protein 1, Nonstructural protein V, Cullin-4A, ...
Authors:Angers, S., Li, T., Yi, X., MacCoss, M.J., Moon, R.T., Zheng, N.
Deposit date:2006-08-05
Release date:2006-10-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
Nature, 443, 2006
4A0C
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STRUCTURE OF THE CAND1-CUL4B-RBX1 COMPLEX
Descriptor:CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1, CULLIN-4B, E3 UBIQUITIN-PROTEIN LIGASE RBX1, ...
Authors:Scrima, A., Fischer, E.S., Faty, M., Gut, H., Thoma, N.H.
Deposit date:2011-09-08
Release date:2011-11-30
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation
Cell(Cambridge,Mass.), 147, 2011
4A0L
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STRUCTURE OF DDB1-DDB2-CUL4B-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX
Descriptor:DNA DAMAGE-BINDING PROTEIN 1, DNA DAMAGE-BINDING PROTEIN 2, CULLIN-4B, ...
Authors:Fischer, E.S., Scrima, A., Gut, H., Thoma, N.H.
Deposit date:2011-09-09
Release date:2011-12-14
Last modified:2012-11-07
Method:X-RAY DIFFRACTION (7.4 Å)
Cite:The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
Cell(Cambridge,Mass.), 147, 2011
4UI9
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ATOMIC STRUCTURE OF THE HUMAN ANAPHASE-PROMOTING COMPLEX
Descriptor:ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, CELL DIVISION CYCLE PROTEIN 23 HOMOLOG, ...
Authors:Chang, L., Zhang, Z., Yang, J., McLaughlin, S.H., Barford, D.
Deposit date:2015-03-27
Release date:2015-06-17
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atomic Structure of the Apc and its Mechanism of Protein Ubiquitination
Nature, 522, 2015
5G04
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STRUCTURE OF THE HUMAN APC-CDC20-HSL1 COMPLEX
Descriptor:ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, CELL DIVISION CYCLE PROTEIN 23 HOMOLOG, ...
Authors:Zhang, S., Chang, L., Alfieri, C., Zhang, Z., Yang, J., Maslen, S., Skehel, M., Barford, D.
Deposit date:2016-03-16
Release date:2016-05-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation.
Nature, 533, 2016
5G05
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CRYO-EM STRUCTURE OF COMBINED APO PHOSPHORYLATED APC
Descriptor:ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, CELL DIVISION CYCLE PROTEIN 23 HOMOLOG, ...
Authors:Zhang, S., Chang, L., Alfieri, C., Zhang, Z., Yang, J., Maslen, S., Skehel, M., Barford, D.
Deposit date:2016-03-16
Release date:2016-05-25
Last modified:2016-06-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation.
Nature, 533, 2016
5KHR
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME COMPLEX (APC15 DELETION MUTANT) IN COMPLEX WITH THE E2 UBE2C/UBCH10 POISED FOR UBIQUITIN LIGATION TO SUBSTRATE (APC/C-CDC20-SUBSTRATE-UBE2C)
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:VanderLinden, R., Yamaguchi, M., Dube, P., Haselbach, D., Stark, H., Schulman, B.A.
Deposit date:2016-06-15
Release date:2016-08-24
Last modified:2016-08-31
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
5KHU
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC15 DELETION MUTANT), IN COMPLEX WITH THE MITOTIC CHECKPOINT COMPLEX (APC/C-CDC20-MCC) BASED ON CRYO EM DATA AT 4.8 ANGSTROM RESOLUTION
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Yamaguchi, M., VanderLinden, R., Dube, P., Stark, H., Schulman, B.
Deposit date:2016-06-15
Release date:2016-09-07
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
5L9T
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH E2 UBE2S POISED FOR POLYUBIQUITINATION WHERE UBE2S, APC2, AND APC11 ARE MODELED INTO LOW RESOLUTION DENSITY
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Brown, N.G., VanderLinden, R., Dube, P., Haselbach, D., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-10-26
Last modified:2016-11-02
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5L9U
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MODEL OF HUMAN ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C-CDH1) WITH A CROSS LINKED UBIQUITIN VARIANT-SUBSTRATE-UBE2C (UBCH10) COMPLEX REPRESENTING KEY FEATURES OF MULTIUBIQUITINATION
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Brown, N.G., VanderLinden, R., Dube, P., Haselbach, D., Peters, J.M., Stark, H., Schulman, B.A.
Deposit date:2016-06-11
Release date:2016-09-14
Method:ELECTRON MICROSCOPY (6.4 Å)
Cite:Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Cell, 165, 2016
5LCW
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CRYO-EM STRUCTURE OF THE ANAPHASE-PROMOTING COMPLEX/CYCLOSOME, IN COMPLEX WITH THE MITOTIC CHECKPOINT COMPLEX (APC/C-MCC) AT 4.2 ANGSTROM RESOLUTION
Descriptor:Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 11, Cell division cycle protein 23 homolog, ...
Authors:Alfieri, C., Chang, L., Zhang, Z., Yang, J., Maslen, S., Skehel, M., Barford, D.
Deposit date:2016-06-22
Release date:2016-08-10
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular basis of APC/C regulation by the spindle assembly checkpoint.
Nature, 536, 2016
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