1YHT
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CRYSTAL STRUCTURE ANALYSIS OF DISPERSIN B
Descriptor:DspB, ACETIC ACID, GLYCEROL
Authors:Ramasubbu, N., Thomas, L.M., Ragunath, C., Kaplan, J.B.
Deposit date:2005-01-10
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Analysis of Dispersin B, a Biofilm-releasing Glycoside Hydrolase from the Periodontopathogen Actinobacillus actinomycetemcomitans.
J.Mol.Biol., 349, 2005
2GK1
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X-RAY CRYSTAL STRUCTURE OF NGT-BOUND HEXA
Descriptor:Beta-hexosaminidase subunit alpha, Beta-hexosaminidase subunit beta, Beta-hexosaminidase subunit beta chain B, ...
Authors:Lemieux, M.J., Mark, B.L., Cherney, M.M., Withers, S.G., Mahuran, D.J., James, M.N.
Deposit date:2006-03-31
Release date:2006-05-30
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystallographic Structure of Human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of G(M2) Ganglioside Hydrolysis.
J.Mol.Biol., 359, 2006
2YL5
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INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Pluvinage, B., Higgins, M.A., Abbott, D.W., Robb, C., Dalia, A.B., Deng, L., Weiser, J.N., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-05-31
Release date:2011-09-14
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
2YL6
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INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Pluvinage, B., Higgins, M.A., Abbott, D.W., Robb, C., Dalia, A.B., Deng, L., Weiser, J.N., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-05-31
Release date:2011-09-14
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
2YL8
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INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, MANGANESE (II) ION, POLYETHYLENE GLYCOL (N=34), ...
Authors:Pluvinage, B., Higgins, M.A., Abbott, D.W., Robb, C., Dalia, A.B., Deng, L., Weiser, J.N., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-05-31
Release date:2011-09-07
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
2YL9
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INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Pluvinage, B., Higgins, M.A., Abbott, D.W., Robb, C., Dalia, A.B., Deng, L., Weiser, J.N., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-06-01
Release date:2011-09-21
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
2YLA
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INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Pluvinage, B., Higgins, M.A., Abbott, D.W., Robb, C., Dalia, A.B., Deng, L., Weiser, J.N., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-06-01
Release date:2011-09-07
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
2YLL
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INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, CALCIUM ION, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Pluvinage, B., Higgins, M.A., Abbott, D.W., Robb, C., Dalia, A.B., Deng, L., Weiser, J.N., Parsons, T.B., Fairbanks, A.J., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-06-02
Release date:2011-09-21
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis.
Structure, 19, 2011
3RPM
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CRYSTAL STRUCTURE OF THE FIRST GH20 DOMAIN OF A NOVEL BETA-N-ACETYL-HEXOSAMINIDASE STRH FROM STREPTOCOCCUS PNEUMONIAE R6
Descriptor:Beta-N-acetyl-hexosaminidase, N-ACETYL-D-GLUCOSAMINE, PENTAETHYLENE GLYCOL
Authors:Jiang, Y.L., Yu, W.L., Zhang, J.W.
Deposit date:2011-04-27
Release date:2011-10-26
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the substrate specificity of a novel beta-N-acetylhexosaminidase StrH protein from Streptococcus pneumoniae R6
J.Biol.Chem., 286, 2011
4AZ5
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, (2S,3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-2,3a,5,6,7,7a-hexahydro-1H-pyrano[3,2-d][1,3]thiazole-6,7-diol, MAGNESIUM ION, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-22
Release date:2013-07-10
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZ6
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, 1,2-ETHANEDIOL, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-23
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZ7
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, LOGNAC, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-23
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZB
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, 1,2-ETHANEDIOL, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-25
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZC
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, (2S,3aR,5R,6S,7R,7aR)-5-(hydroxymethyl)-2-methyl-2,3a,5,6,7,7a-hexahydro-1H-pyrano[3,2-d][1,3]thiazole-6,7-diol, MAGNESIUM ION, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-25
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZG
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, ACETATE ION, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-25
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZH
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, LOGNAC, 1,2-ETHANEDIOL
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-26
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
4AZI
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DIFFERENTIAL INHIBITION OF THE TANDEM GH20 CATALYTIC MODULES IN THE PNEUMOCOCCAL EXO-BETA-D-N-ACETYLGLUCOSAMINIDASE, STRH
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, 1,2-ETHANEDIOL, ...
Authors:Pluvinage, B., Stubbs, K.A., Vocadlo, D.J., Boraston, A.B.
Deposit date:2012-06-26
Release date:2013-07-10
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Inhibition of the Family 20 Glycoside Hydrolase Catalytic Modules in the Streptococcus Pneumoniae Exo-Beta-D-N-Acetylglucosaminidase, Strh.
Org.Biomol.Chem., 11, 2013
5OAR
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CRYSTAL STRUCTURE OF NATIVE BETA-N-ACETYLHEXOSAMINIDASE ISOLATED FROM ASPERGILLUS ORYZAE
Descriptor:Beta-hexosaminidase, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Skerlova, J., Rezacova, P., Brynda, J., Pachl, P., Otwinowski, Z., Vanek, O.
Deposit date:2017-06-23
Release date:2017-12-27
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of native beta-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide.
FEBS J., 285, 2018
1C7S
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BETA-N-ACETYLHEXOSAMINIDASE MUTANT D539A COMPLEXED WITH DI-N-ACETYL-BETA-D-GLUCOSAMINE (CHITOBIASE)
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, DI(N-ACETYL-D-GLUCOSAMINE), SULFATE ION
Authors:Prag, G., Papanikolau, Y., Tavlas, G., Vorgias, C.E., Petratos, K., Oppenheim, A.B.
Deposit date:2000-03-14
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540.
J.Mol.Biol., 300, 2000
1C7T
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BETA-N-ACETYLHEXOSAMINIDASE MUTANT E540D COMPLEXED WITH DI-N ACETYL-D-GLUCOSAMINE (CHITOBIASE)
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, DI(N-ACETYL-D-GLUCOSAMINE), SULFATE ION
Authors:Prag, G., Papanikolau, Y., Tavlas, G., Vorgias, C.E., Petratos, K., Oppenheim, A.B.
Deposit date:2000-03-17
Release date:2000-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540.
J.Mol.Biol., 300, 2000
1HP4
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CRYSTAL STRUCTURE OF STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, SULFATE ION, ...
Authors:Mark, B.L.
Deposit date:2000-12-12
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
J.Biol.Chem., 276, 2001
1HP5
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE COMPLEXED WITH INTERMEDIATE ANALOUGE NAG-THIAZOLINE
Descriptor:BETA-N-ACETYLHEXOSAMINIDASE, CHLORIDE ION, SULFATE ION, ...
Authors:Mark, B.L.
Deposit date:2000-12-12
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
J.Biol.Chem., 276, 2001
1JAK
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE IN COMPLEX WITH (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINIUM CHLORIDE (IFG)
Descriptor:Beta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ...
Authors:Mark, B.L., Vocadlo, D.J., Zhao, D., Knapp, S., Withers, S.G., James, M.N.
Deposit date:2001-05-30
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
J.Biol.Chem., 276, 2001
1M01
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WILDTYPE STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:J Williams, S., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2003-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
1M03
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MUTANT STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE (D313A) IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2002-12-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
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