6E4T
  • Download 6e4t
  • View 6e4t
Molmil generated image of 6e4t
STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4U
  • Download 6e4u
  • View 6e4u
Molmil generated image of 6e4u
STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
6E4W
  • Download 6e4w
  • View 6e4w
Molmil generated image of 6e4w
STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2018-07-18
Release date:2018-08-08
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J. Med. Chem., 61, 2018
5YZ2
  • Download 5yz2
  • View 5yz2
Molmil generated image of 5yz2
THE CYSTATHIONINE-BETA-SYNTHASE (CBS) DOMAIN OF MAGNESIUM AND COBALT EFFLUX PROTEIN CORC IN COMPLEX WITH BOTH C2'- AND C3'-ENDO AMP
Descriptor:Magnesium and cobalt efflux protein CorC, ADENOSINE MONOPHOSPHATE
Authors:Feng, N., Qi, C., Li, D.F., Wang, D.C.
Deposit date:2017-12-12
Release date:2018-05-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain.
Biochem. Biophys. Res. Commun., 497, 2018
6B1U
  • Download 6b1u
  • View 6b1u
Molmil generated image of 6b1u
STRUCTURE OF FULL-LENGTH HUMAN AMPK (A2B1G1) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR SC4
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Ngoei, K.R.W., Langendorf, C.G., Ling, N.X.Y., Hoque, A., Johnson, S., Camerino, M.C., Walker, S.R., Bozikis, Y.E., Dite, T.A., Ovens, A.J., Smiles, W.J., Jacobs, R., Huang, H., Parker, M.W., Scott, J.W., Rider, M.H., Kemp, B.E., Foitzik, R.C., Baell, J.B., Oakhill, J.S.
Deposit date:2017-09-19
Release date:2018-04-25
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
Cell Chem Biol, 25, 2018
6B2E
  • Download 6b2e
  • View 6b2e
Molmil generated image of 6b2e
STRUCTURE OF FULL LENGTH HUMAN AMPK (A2B2G1) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR SC4.
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Ngoei, K.R.W., Langendorf, C.G., Ling, N.X.Y., Hoque, A., Johnson, S., Camerino, M.C., Walker, S.R., Bozikis, Y.E., Dite, T.A., Ovens, A.J., Smiles, W.J., Jacobs, R., Huang, H., Parker, M.W., Scott, J.W., Rider, M.H., Kemp, B.E., Foitzik, R.C., Baell, J.B., Oakhill, J.S.
Deposit date:2017-09-19
Release date:2018-04-25
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK alpha 2 beta 2 gamma 1 by the Glucose Importagog SC4.
Cell Chem Biol, 25, 2018
5NVD
  • Download 5nvd
  • View 5nvd
Molmil generated image of 5nvd
CRYSTAL STRUCTURE OF HEXAMERIC CBS-CP12 PROTEIN FROM BLOOM-FORMING CYANOBACTERIA AT 2.5 A RESOLUTION IN P6322 CRYSTAL FORM
Descriptor:CBS-CP12
Authors:Hackenberg, C., Hakanpaa, J., Eigner, C., Antonyuk, S.V., Dittmann, E., Lamzin, V.S.
Deposit date:2017-05-04
Release date:2018-05-30
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NPL
  • Download 5npl
  • View 5npl
Molmil generated image of 5npl
CRYSTAL STRUCTURE OF HEXAMERIC CBS-CP12 PROTEIN FROM BLOOM-FORMING CYANOBACTERIA, YB-DERIVATIVE AT 2.8 A RESOLUTION
Descriptor:Similar to tr|Q8YYT1|Q8YYT1, YTTERBIUM (III) ION, 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID
Authors:Hackenberg, C., Hakanpaa, J., Antonyuk, S.V., Dittmann, E., Lamzin, V.S.
Deposit date:2017-04-17
Release date:2018-05-30
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NMU
  • Download 5nmu
  • View 5nmu
Molmil generated image of 5nmu
STRUCTURE OF HEXAMERIC CBS-CP12 PROTEIN FROM BLOOM-FORMING CYANOBACTERIA
Descriptor:CBS-CP12, CHLORIDE ION
Authors:Hackenberg, C., Hakanpaa, J., Antonyuk, S.V., Dittmann, E., Lamzin, V.S.
Deposit date:2017-04-07
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural and functional insights into the unique CBS-CP12 fusion protein family in cyanobacteria.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5X9G
  • Download 5x9g
  • View 5x9g
Molmil generated image of 5x9g
CRYSTAL STRUCTURE OF THE CYTOSOLIC DOMAIN OF THE MG2+ CHANNEL MGTE IN COMPLEX WITH ATP
Descriptor:Magnesium transporter MgtE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Tomita, A., Hattori, M., Nureki, O.
Deposit date:2017-03-07
Release date:2017-08-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:ATP-dependent modulation of MgtE in Mg(2+) homeostasis
Nat Commun, 8, 2017
5X9H
  • Download 5x9h
  • View 5x9h
Molmil generated image of 5x9h
CRYSTAL STRUCTURE OF THE MG2+ CHANNEL MGTE IN COMPLEX WITH ATP
Descriptor:Magnesium transporter MgtE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Tomita, A., Hattori, M., Nureki, O.
Deposit date:2017-03-07
Release date:2017-08-16
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:ATP-dependent modulation of MgtE in Mg(2+) homeostasis
Nat Commun, 8, 2017
5X8O
  • Download 5x8o
  • View 5x8o
Molmil generated image of 5x8o
CRYSTAL STRUCTURE OF GMP REDUCTASE FROM TRYPANOSOMA BRUCEI WITH GUANOSINE 5'-TRIPHOSPHATE
Descriptor:Inosine-5'-monophosphate dehydrogenase, GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION
Authors:Otani, T., Imamura, A., Sugiyama, S., Nishimura, S., Inui, T.
Deposit date:2017-03-03
Release date:2018-03-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of GMP reductase from Trypanosoma brucei with guanosine 5'-triphosphate
To Be Published
5UFU
  • Download 5ufu
  • View 5ufu
Molmil generated image of 5ufu
STRUCTURE OF AMPK BOUND TO ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2017-01-05
Release date:2017-05-17
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.
Cell Metab., 25, 2017
5MMZ
  • Download 5mmz
  • View 5mmz
Molmil generated image of 5mmz
STRUCTURE OF PRL-1 IN COMPLEX WITH THE BATEMAN DOMAIN OF CNNM2
Descriptor:Metal transporter CNNM2, Protein tyrosine phosphatase type IVA 1
Authors:Gimenez-Mascarell, P., Oyenarte, I., Hardy, S., Breiderhoff, T., Stuiver, M., Kostantin, E., Diercks, T., Pey, A.L., Ereno-Orbea, J., Martinez-Chantar, M.L., Khalaf-Nazzal, R., Claverie-Martin, F., Muller, D., Tremblay, M.L., Martinez-Cruz, L.A.
Deposit date:2016-12-12
Release date:2016-12-21
Last modified:2017-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
J. Biol. Chem., 292, 2017
5MCP
  • Download 5mcp
  • View 5mcp
Molmil generated image of 5mcp
STRUCTURE OF IMP DEHYDROGENASE FROM ASHBYA GOSSYPII BOUND TO ATP
Descriptor:Inosine-5'-monophosphate dehydrogenase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Winter, G., Fernandez-Justel, D., de Pereda, J.M., Revuelta, J.L., Buey, R.M.
Deposit date:2016-11-10
Release date:2017-06-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
Sci Rep, 7, 2017
5TSR
  • Download 5tsr
  • View 5tsr
Molmil generated image of 5tsr
CRYSTAL STRUCTURE OF PRL-3 PHOSPHATASE IN COMPLEX WITH THE BATEMAN DOMAIN OF CNNM3 MAGNESIUM TRANSPORTER
Descriptor:Protein tyrosine phosphatase type IVA 3, Metal transporter CNNM3
Authors:Kozlov, G., Zhang, H., Gehring, K.
Deposit date:2016-10-31
Release date:2017-02-08
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3.188 Å)
Cite:PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Sci Rep, 7, 2017
5LXQ
  • Download 5lxq
  • View 5lxq
Molmil generated image of 5lxq
STRUCTURE OF PRL-1 IN COMPLEX WITH THE BATEMAN DOMAIN OF CNNM2
Descriptor:Protein tyrosine phosphatase type IVA 1, Metal transporter CNNM2, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:GIMENEZ-Mascarell, P., Oyenarte, I., HARDY, S., Breiderhoff, T., STUIVER, M., Kostantin, E., Diercks, T., Pey, A.L., Ereno-ORBEA, J., Martinez-Chantar, M.L., Khalaf-Nazzal, R., Claverie-Martin, F., MULLER, D., TREMBLAY, M., Martinez-Cruz, L.A.
Deposit date:2016-09-22
Release date:2016-12-07
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (3.335 Å)
Cite:Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
J. Biol. Chem., 292, 2017
5TC3
  • Download 5tc3
  • View 5tc3
Molmil generated image of 5tc3
STRUCTURE OF IMP DEHYDROGENASE FROM ASHBYA GOSSYPII BOUND TO ATP AND GDP
Descriptor:Inosine-5'-monophosphate dehydrogenase, GUANOSINE-5'-MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Fernandez-Justel, D., de Pereda, J.M., Revuelta, J.L., Buey, R.M.
Deposit date:2016-09-14
Release date:2017-06-14
Method:X-RAY DIFFRACTION (2.462 Å)
Cite:A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
Sci Rep, 7, 2017
5T5T
  • Download 5t5t
  • View 5t5t
Molmil generated image of 5t5t
AMPK BOUND TO ALLOSTERIC ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2016-08-31
Release date:2017-03-29
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.
J. Pharmacol. Exp. Ther., 361, 2017
5KS7
  • Download 5ks7
  • View 5ks7
Molmil generated image of 5ks7
CRYSTAL STRUCTURE OF LISTERIA MONOCYTOGENES OPUCA CBS DOMAIN DIMER IN COMPLEX WITH CYCLIC-DI-AMP
Descriptor:Carnitine transport ATP-binding protein OpuCA, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide
Authors:Choi, P.H., Tong, L.
Deposit date:2016-07-07
Release date:2016-07-20
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC.
Mol.Microbiol., 102, 2016
5KQ5
  • Download 5kq5
  • View 5kq5
Molmil generated image of 5kq5
AMPK BOUND TO ALLOSTERIC ACTIVATOR
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Calabrese, M.F., Kurumbail, R.G.
Deposit date:2016-07-05
Release date:2016-08-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J.Med.Chem., 59, 2016
5G5X
  • Download 5g5x
  • View 5g5x
Molmil generated image of 5g5x
CBS DOMAIN TANDEM OF SITE-2 PROTEASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH LLAMA NANOBODY - NUCLEOTIDE-BOUND FORM
Descriptor:SITE-2 PROTEASE, NANOBODY, ADENOSINE MONOPHOSPHATE, ...
Authors:Schacherl, M., Baumann, U.
Deposit date:2016-06-09
Release date:2017-05-24
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.
Biochim. Biophys. Acta, 1859, 2017
5G5R
  • Download 5g5r
  • View 5g5r
Molmil generated image of 5g5r
CBS DOMAIN TANDEM OF SITE-2 PROTEASE FROM ARCHAEOGLOBUS FULGIDUS IN COMPLEX WITH LLAMA NANOBODY - APO FORM
Descriptor:SITE-2 PROTEASE, NANOBODY, SULFATE ION
Authors:Schacherl, M., Baumann, U.
Deposit date:2016-06-02
Release date:2017-05-24
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and biochemical characterization of the dimeric architecture of site-2 protease.
Biochim. Biophys. Acta, 1859, 2017
5K22
  • Download 5k22
  • View 5k22
Molmil generated image of 5k22
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN PRL-2 PHOSPHATASE IN REDUCED STATE AND BATEMAN DOMAIN OF HUMAN CNNM3
Descriptor:Protein tyrosine phosphatase type IVA 2, Metal transporter CNNM3
Authors:Kozlov, G., Wu, H., Gehring, K.
Deposit date:2016-05-18
Release date:2016-10-12
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.
EMBO Rep., 17, 2016
5K23
  • Download 5k23
  • View 5k23
Molmil generated image of 5k23
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN PHOSPHATASE PRL-2 IN THE OXIDIZED STATE WITH THE BATEMAN DOMAIN OF HUMAN MAGNESIUM TRANSPORTER CNNM3
Descriptor:Protein tyrosine phosphatase type IVA 2, Metal transporter CNNM3
Authors:Gulerez, I., Kozlov, G., Gehring, K.
Deposit date:2016-05-18
Release date:2016-10-12
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3.
Sci Rep, 7, 2017
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2018 Protein Data Bank Japan