3O53
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CRYSTAL STRUCTURE OF LRIM1 LEUCINE-RICH REPEAT DOMAIN
Descriptor:COBALT (II) ION, N-ACETYL-D-GLUCOSAMINE, Protein LRIM1
Authors:Baxter, R.H.G., Steinert, S., Chelliah, Y., Volohonsky, G., Levashina, E.A., Deisenhofer, J.
Deposit date:2010-07-27
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae.
Proc.Natl.Acad.Sci.USA, 107, 2010
3OJA
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CRYSTAL STRUCTURE OF LRIM1/APL1C COMPLEX
Descriptor:ALPHA-D-MANNOSE, Anopheles Plasmodium-responsive Leucine-rich repeat protein 1, Leucine-rich Immune Molecule 1, ...
Authors:Baxter, R.H.G., Deisenhofer, J.
Deposit date:2010-08-20
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae.
Proc.Natl.Acad.Sci.USA, 107, 2010
3B2D
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CRYSTAL STRUCTURE OF HUMAN RP105/MD-1 COMPLEX
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, CD180 antigen, ...
Authors:Ohto, U., Shimizu, T.
Deposit date:2011-07-29
Release date:2011-11-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
J.Mol.Biol., 413, 2011
3CIG
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CRYSTAL STRUCTURE OF MOUSE TLR3 ECTODOMAIN
Descriptor:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ALPHA-D-MANNOSE, ALPHA-L-FUCOSE, ...
Authors:Liu, L., Botos, I., Wang, Y., Leonard, J.N., Shiloach, J., Segal, D.M., Davies, D.R.
Deposit date:2008-03-11
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Science, 320, 2008
3CIY
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MOUSE TOLL-LIKE RECEPTOR 3 ECTODOMAIN COMPLEXED WITH DOUBLE-STRANDED RNA
Descriptor:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, 46-MER, ALPHA-D-MANNOSE, ...
Authors:Liu, L., Botos, I., Wang, Y., Leonard, J.N., Shiloach, J., Segal, D.M., Davies, D.R.
Deposit date:2008-03-12
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
Science, 320, 2008
3RG1
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CRYSTAL STRUCTURE OF THE RP105/MD-1 COMPLEX
Descriptor:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Yoon, S.I., Hong, M., Wilson, I.A.
Deposit date:2011-04-07
Release date:2011-08-31
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1.
Nat.Struct.Mol.Biol., 18, 2011
3RGX
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STRUCTURAL INSIGHT INTO BRASSINOSTEROID PERCEPTION BY BRI1
Descriptor:N-ACETYL-D-GLUCOSAMINE, Protein BRASSINOSTEROID INSENSITIVE 1
Authors:Chai, J., Han, Z., She, J., Wang, J., Cheng, W., Wang, J.
Deposit date:2011-04-11
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural insight into brassinosteroid perception by BRI1.
Nature, 474, 2011
3RGZ
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STRUCTURAL INSIGHT INTO BRASSINOSTEROID PERCEPTION BY BRI1
Descriptor:Brassinolide, N-ACETYL-D-GLUCOSAMINE, Protein BRASSINOSTEROID INSENSITIVE 1, ...
Authors:Chai, J., Han, Z., She, J., Wang, J., Cheng, W.
Deposit date:2011-04-11
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.281 Å)
Cite:Structural insight into brassinosteroid perception by BRI1.
Nature, 474, 2011
3RIZ
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CRYSTAL STRUCTURE OF THE PLANT STEROID RECEPTOR BRI1 ECTODOMAIN
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hothorn, M.
Deposit date:2011-04-14
Release date:2011-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.523 Å)
Cite:Structural basis of steroid hormone perception by the receptor kinase BRI1.
Nature, 474, 2011
3RJ0
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PLANT STEROID RECEPTOR BRI1 ECTODOMAIN IN COMPLEX WITH BRASSINOLIDE
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, Brassinolide, ...
Authors:Hothorn, M.
Deposit date:2011-04-14
Release date:2011-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.541 Å)
Cite:Structural basis of steroid hormone perception by the receptor kinase BRI1.
Nature, 474, 2011
3W3G
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CRYSTAL STRUCTURE OF HUMAN TLR8 (UNLIGANDED FORM)
Descriptor:(R,R)-2,3-BUTANEDIOL, BETA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2012-12-21
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3J
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CRYSTAL STRUCTURE OF HUMAN TLR8 IN COMPLEX WITH CL097
Descriptor:2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-4-amine, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3K
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CRYSTAL STRUCTURE OF HUMAN TLR8 IN COMPLEX WITH CL075
Descriptor:2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3L
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CRYSTAL STRUCTURE OF HUMAN TLR8 IN COMPLEX WITH RESIQUIMOD (R848) CRYSTAL FORM 1
Descriptor:1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3M
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CRYSTAL STRUCTURE OF HUMAN TLR8 IN COMPLEX WITH RESIQUIMOD (R848) CRYSTAL FORM 2
Descriptor:1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3W3N
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CRYSTAL STRUCTURE OF HUMAN TLR8 IN COMPLEX WITH RESIQUIMOD (R848) CRYSTAL FORM 3
Descriptor:1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2012-12-22
Release date:2013-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3WN4
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CRYSTAL STRUCTURE OF HUMAN TLR8 IN COMPLEX WITH DS-877
Descriptor:2-butylfuro[2,3-c]quinolin-4-amine, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Tanji, H., Ohto, U., Shimizu, T.
Deposit date:2013-12-02
Release date:2014-02-19
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists.
Chemmedchem, 2014
4LSA
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CRYSTAL STRUCTURE OF BRI1 SUD1 (GLY643GLU) BOUND TO BRASSINOLIDE
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, Brassinolide, ...
Authors:Santiago, J., Henzler, C., Hothorn, M.
Deposit date:2013-07-22
Release date:2013-09-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
Science, 341, 2013
4LSC
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ISOLATED SERK1 CO-RECEPTOR ECTODOMAIN AT HIGH RESOLUTION
Descriptor:ALPHA-L-FUCOSE, BETA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Santiago, J., Henzler, C., Hothorn, M.
Deposit date:2013-07-22
Release date:2013-09-04
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
Science, 341, 2013
4LSX
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PLANT STEROID RECEPTOR ECTODOMAIN BOUND TO BRASSINOLIDE AND SERK1 CO-RECEPTOR ECTODOMAIN
Descriptor:ALPHA-D-MANNOSE, BETA-D-MANNOSE, Brassinolide, ...
Authors:Santiago, J., Henzler, C., Hothorn, M.
Deposit date:2013-07-23
Release date:2013-09-04
Method:X-RAY DIFFRACTION (3.302 Å)
Cite:Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases.
Science, 341, 2013
4LXR
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STRUCTURE OF THE TOLL - SPATZLE COMPLEX, A MOLECULAR HUB IN DROSOPHILA DEVELOPMENT AND INNATE IMMUNITY
Descriptor:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Stelter, M., Parthier, C., Breithaupt, C., Stubbs, M.T.
Deposit date:2013-07-30
Release date:2014-04-09
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.
Proc.Natl.Acad.Sci.USA, 111, 2014
4LXS
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STRUCTURE OF THE TOLL - SPATZLE COMPLEX, A MOLECULAR HUB IN DROSOPHILA DEVELOPMENT AND INNATE IMMUNITY (GLYCOSYLATED FORM)
Descriptor:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Stelter, M., Parthier, C., Breithaupt, C., Stubbs, M.T.
Deposit date:2013-07-30
Release date:2014-04-09
Last modified:2014-05-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.
Proc.Natl.Acad.Sci.USA, 111, 2014
4M7E
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STRUCTURAL INSIGHT INTO BL-INDUCED ACTIVATION OF THE BRI1-BAK1 COMPLEX
Descriptor:BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1, Brassinolide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chai, J., Han, Z., Sun, Y.
Deposit date:2013-08-12
Release date:2013-10-16
Method:X-RAY DIFFRACTION (3.602 Å)
Cite:Structural insight into BL-induced activation of the BRI1-BAK1 complex
To be Published
4MN8
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CRYSTAL STRUCTURE OF FLG22 IN COMPLEX WITH THE FLS2 AND BAK1 ECTODOMAINS
Descriptor:BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1, LRR receptor-like serine/threonine-protein kinase FLS2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Chai, J., Sun, Y., Han, Z.
Deposit date:2013-09-10
Release date:2013-12-04
Method:X-RAY DIFFRACTION (3.062 Å)
Cite:Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex.
Science, 342, 2013
4MNA
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CRYSTAL STRUCTURE OF THE FREE FLS2 ECTODOMAINS
Descriptor:LRR receptor-like serine/threonine-protein kinase FLS2, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Chai, J., Han, Z., Sun, Y.
Deposit date:2013-09-10
Release date:2013-12-04
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (3.998 Å)
Cite:Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex.
Science, 342, 2013
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