5A1I
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THE STRUCTURE OF HUMAN MAT2A IN COMPLEX WITH SAM, ADENOSINE, METHIONINE AND PPNP.
Descriptor:S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2, METHIONINE, (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ...
Authors:Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.
Deposit date:2015-04-30
Release date:2016-03-09
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes.
Proc.Natl.Acad.Sci.USA, 113, 2016
2P02
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CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2
Descriptor:S-adenosylmethionine synthetase isoform type-2, CHLORIDE ION, S-ADENOSYLMETHIONINE
Authors:Papagrigoriou, E., Shafqat, N., Rojkova, A., Niessen, F.H., Kavanagh, K.L., von Delft, F., Gorrec, F., Ugochukwu, E., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-02-28
Release date:2007-03-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2
To be Published
5T8S
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CRYSTAL STRUCTURE OF A S-ADENOSYLMETHIONINE SYNTHASE FROM NEISSERIA GONORRHOEAE WITH BOUND S-ADENOSYLMETHIONINE, AMP, PYROPHOSPHATE, PHOSPHATE, AND MAGNESIUM
Descriptor:S-adenosylmethionine synthase, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-09-08
Release date:2016-09-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound S-adenosylmethionine, AMP, Pyrophosphate, Phosphate, and Magnesium
to be published
3S82
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STRUCTURE OF A S-ADENOSYLMETHIONINE SYNTHETASE FROM MYCOBACTERIUM AVIUM
Descriptor:S-adenosylmethionine synthase, CALCIUM ION, UNKNOWN LIGAND, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-05-27
Release date:2011-06-08
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
5A1G
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THE STRUCTURE OF HUMAN MAT2A IN COMPLEX WITH S-ADENOSYLETHIONINE AND PPNP.
Descriptor:S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2, (4S)-2-METHYL-2,4-PENTANEDIOL, (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ...
Authors:Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.
Deposit date:2015-04-30
Release date:2016-02-17
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes.
Proc.Natl.Acad.Sci.USA, 113, 2016
3TDE
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE RV1392 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:S-adenosylmethionine synthase, SODIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-08-10
Release date:2011-08-17
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
3RV2
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE FROM MYCOBACTERIUM MARINUM
Descriptor:S-adenosylmethionine synthase, CALCIUM ION, 1,2-ETHANEDIOL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2011-05-05
Release date:2011-05-18
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Increasing the structural coverage of tuberculosis drug targets.
Tuberculosis (Edinb), 95, 2015
2OBV
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CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT
Descriptor:S-adenosylmethionine synthetase isoform type-1, SODIUM ION, S-ADENOSYLMETHIONINE, ...
Authors:Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-02
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
5UGH
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CRYSTAL STRUCTURE OF MAT2A BOUND TO THE ALLOSTERIC INHIBITOR PF-02929366
Descriptor:S-adenosylmethionine synthase isoform type-2, 2-(7-chloro-5-phenyl[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethan-1-amine
Authors:Kaiser, S.E., Feng, J., Stewart, A.E.
Deposit date:2017-01-08
Release date:2017-05-17
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.062 Å)
Cite:Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.
Nat. Chem. Biol., 13, 2017
5T8T
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CRYSTAL STRUCTURE OF A S-ADENOSYLMETHIONINE SYNTHASE FROM NEISSERIA GONORRHOEAE WITH BOUND AMP AND MAGNESIUM
Descriptor:S-adenosylmethionine synthase, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2016-09-08
Release date:2016-09-28
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound AMP and Magnesium
to be published
4NDN
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STRUCTURAL INSIGHTS OF MAT ENZYMES: MATA2B COMPLEXED WITH SAM AND PPNP
Descriptor:S-adenosylmethionine synthase isoform type-2, Methionine adenosyltransferase 2 subunit beta, MAGNESIUM ION, ...
Authors:Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.
Deposit date:2013-10-27
Release date:2014-07-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure and function study of the complex that synthesizes S-adenosylmethionine.
IUCrJ, 1, 2014
5A19
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THE STRUCTURE OF MAT2A IN COMPLEX WITH PPNP.
Descriptor:S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-2, DI(HYDROXYETHYL)ETHER, (DIPHOSPHONO)AMINOPHOSPHONIC ACID, ...
Authors:Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.
Deposit date:2015-04-28
Release date:2016-02-17
Last modified:2016-03-09
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystallography Captures Catalytic Steps in Human Methionine Adenosyltransferase Enzymes.
Proc.Natl.Acad.Sci.USA, 113, 2016
3IML
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE FROM BURKHOLDERIA PSEUDOMALLEI
Descriptor:S-adenosylmethionine synthetase
Authors:Staker, B.L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-08-10
Release date:2009-09-22
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Combining functional and structural genomics to sample the essential Burkholderia structome.
Plos One, 8, 2013
1P7L
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S-ADENOSYLMETHIONINE SYNTHETASE COMPLEXED WITH AMPPNP AND MET.
Descriptor:S-adenosylmethionine synthetase, POTASSIUM ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Komoto, J.
Deposit date:2003-05-02
Release date:2004-03-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
1RG9
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S-ADENOSYLMETHIONINE SYNTHETASE COMPLEXED WITH SAM AND PPNP
Descriptor:S-adenosylmethionine synthetase, POTASSIUM ION, MAGNESIUM ION, ...
Authors:Komoto, J., Yamada, T., Takata, Y., Markham, G.D., Takusagawa, F.
Deposit date:2003-11-11
Release date:2004-03-02
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
4KTT
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STRUCTURAL INSIGHTS OF MAT ENZYMES: MATA2B COMPLEXED WITH SAM
Descriptor:S-adenosylmethionine synthase isoform type-2, Methionine adenosyltransferase 2 subunit beta, 1,2-ETHANEDIOL, ...
Authors:Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.
Deposit date:2013-05-21
Release date:2014-07-16
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure and function study of the complex that synthesizes S-adenosylmethionine.
IUCrJ, 1, 2014
1QM4
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METHIONINE ADENOSYLTRANSFERASE COMPLEXED WITH A L-METHIONINE ANALOGUE
Descriptor:METHIONINE ADENOSYLTRANSFERASE, ALPHA FORM, L-2-AMINO-4-METHOXY-CIS-BUT-3-ENOIC ACID, ...
Authors:Gonzalez, B., Pajares, M.A., Hermoso, J.A., Sanz-Aparicio, J.
Deposit date:1999-09-20
Release date:2000-09-21
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:The Crystal Structure of Tetrameric Methionine Adenosyltransferase from Rat Liver Reveals the Methionine-Binding Site
J.Mol.Biol., 300, 2000
5H9U
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CRYSTAL STRUCTURE OF A THERMOSTABLE METHIONINE ADENOSYLTRANSFERASE
Descriptor:S-adenosylmethionine synthase
Authors:Feng, Y., Wang, W.
Deposit date:2015-12-29
Release date:2017-01-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.667 Å)
Cite:Crystal structure of a thermostable methionine adenosyltransferase
To Be Published
1MXA
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S-ADENOSYLMETHIONINE SYNTHETASE WITH PPI
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1MXB
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S-ADENOSYLMETHIONINE SYNTHETASE WITH ADP
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1O9T
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METHIONINE ADENOSYLTRANSFERASE COMPLEXED WITH BOTH SUBSTRATES ATP AND METHIONINE
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, METHIONINE, PHOSPHATE ION, ...
Authors:Gonzalez, B., Pajares, M.A., Hermoso, J.A., Sanz-Aparicio, J.
Deposit date:2002-12-18
Release date:2003-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Methionine Adenosyltransferase Complexed with Substrates and Products Reveal the Methionine-ATP Recognition and Give Insights Into the Catalytic Mechanism
J.Mol.Biol., 331, 2003
1MXC
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S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1XRA
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Misaki, S., Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRB
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S-ADENOSYLMETHIONINE SYNTHETASE (MAT, ATP: L-METHIONINE S-ADENOSYLTRANSFERASE, E.C.2.5.1.6) IN WHICH MET RESIDUES ARE REPLACED WITH SELENOMETHIONINE RESIDUES (MSE)
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Takusagawa, F., Kamitori, S., Misaki, S., Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRC
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CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor:S-ADENOSYLMETHIONINE SYNTHETASE, PHOSPHATE ION, COBALT (II) ION, ...
Authors:Takusagawa, F., Kamitori, S., Misaki, S., Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
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