PDB: 145 resultsInfo pagesStatus searchChemie searchBIRD

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8QVO	L211Q, L254N, T262G mutant of carboxypeptidase T from Thermoactinomyces vulgaris Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Dorovatovskii, P.V, Lazarenko, V.A, Akparov, V.K, Kuranova, I.P. Deposit date: 2023-10-18 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.96 Å) Cite: L211Q, L254N, T262G mutant of carboxypeptidase T from Thermoactinomyces vulgaris To Be Published
8CPA	COMPARISON OF THE STRUCTURES OF THREE CARBOXYPEPTIDASE A-PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY Descriptor: CARBOXYPEPTIDASE A, O-(((1R)-((N-(PHENYL-METHOXY-CARBONYL)-ALANYL)-AMINO)METHYL)HYDROXYPHOSPHINYL)3-L-PHENYLLACTATE, ZINC ION Authors: Kim, H, Lipscomb, W.N. Deposit date: 1991-05-21 Release date: 1994-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography. Biochemistry, 30, 1991
7Q87	Carboxypeptidase T with (S)-3-phenyllactic acid Descriptor: ALPHA-HYDROXY-BETA-PHENYL-PROPIONIC ACID, CALCIUM ION, Carboxypeptidase T, ... Authors: Timofeev, V.I, Akparov, V.K, Shevtsov, M.B, Kuranova, I.P. Deposit date: 2021-11-10 Release date: 2022-01-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Carboxypeptidase T with (S)-3-phenyllactic acid To Be Published
7NEU	Inhibitor Complex with Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) Descriptor: (1R,3S)-3-(4-ammoniobutyl)-1-(4-fluoro-2-(1-methyl-1H-imidazol-5-yl)benzyl)-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Brown, D.G, Schaffner, A.P, Vuillard, L.M, Gloanec, P, Raimbauld, E. Deposit date: 2021-02-04 Release date: 2021-04-07 Last modified: 2021-04-21 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J.Med.Chem., 64, 2021
7NEE	Inhibitor Complex with Thrombin Activatable Fibrinolysis inhibitor (TAFIa) Descriptor: (1R,3S)-3-(4-ammoniobutyl)-1-benzyl-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, Carboxypeptidase B2, ZINC ION Authors: Brown, D.G, Schaffner, A.P, Gloanec, P, Raimbaud, E, Vuillard, L.M. Deposit date: 2021-02-03 Release date: 2021-04-07 Last modified: 2021-04-21 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J.Med.Chem., 64, 2021
7EQZ	Crystal structure of Carboxypeptidase B complexed with Potato Carboxypeptidase Inhibitor Descriptor: Carboxypeptidase B, GLYCINE, Metallocarboxypeptidase inhibitor, ... Authors: Choong, Y.K, Gavor, E, Jobichen, C, Sivaraman, J. Deposit date: 2021-05-05 Release date: 2021-11-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism. Protein Sci., 30, 2021
7EQX	Crystal structure of an Aedes aegypti procarboxypeptidase B1 Descriptor: Carboxypeptidase B, ZINC ION Authors: Choong, Y.K, Gavor, E, Jobichen, C, Sivaraman, J. Deposit date: 2021-05-05 Release date: 2021-11-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Structure of Aedes aegypti procarboxypeptidase B1 and its binding with Dengue virus for controlling infection. Life Sci Alliance, 5, 2022
7CPA	COMPARISON OF THE STRUCTURES OF THREE CARBOXYPEPTIDASE A-PHOSPHONATE COMPLEXES DETERMINED BY X-RAY CRYSTALLOGRAPHY Descriptor: CARBOXYPEPTIDASE A, O-((((N-PHENYL-METHOXY-CARBONYL)-PHENYL ALANYL-CARBONYL)AMINO)-ISOBUTYL)HYDROXY PHOSPHINYL)-3-PHENYLACETIC ACID, ZINC ION Authors: Kim, H, Lipscomb, W.N. Deposit date: 1991-05-21 Release date: 1994-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Comparison of the structures of three carboxypeptidase A-phosphonate complexes determined by X-ray crystallography. Biochemistry, 30, 1991
7ARU	L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine Descriptor: (2~{S})-3-methyl-2-(sulfamoylamino)butanoic acid, CALCIUM ION, Carboxypeptidase T, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2020-10-26 Release date: 2020-11-11 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.05 Å) Cite: L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine To Be Published
7AQP	T262S, A251S, L254S, L211Q mutant of carboxypeptidase T from Thermoactinomyces vulgaris Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2020-10-22 Release date: 2020-12-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.6 Å) Cite: T262S, A251S, L254S, L211Q mutant of carboxypeptidase T from Thermoactinomyces vulgaris To Be Published
6Z28	Carboxypeptidase T mutant L254N with N-sulfamoyl-L-glutamic acid Descriptor: CALCIUM ION, Carboxypeptidase T, N-sulfamoyl-L-glutamic acid, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2020-05-15 Release date: 2020-05-27 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: CARBOXYPEPTIDASE T MUTANT L254N WITH WITH N-SULFAMOYL-L-GLUT To Be Published
6TNK	CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-VALINE Descriptor: (2~{S})-3-methyl-2-(sulfamoylamino)butanoic acid, CALCIUM ION, Carboxypeptidase T, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2019-12-09 Release date: 2019-12-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-VALINE To Be Published
6T9Y	CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-LYSIN Descriptor: (2~{S})-6-azanyl-2-(sulfamoylamino)hexanoic acid, CALCIUM ION, Carboxypeptidase T, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2019-10-29 Release date: 2019-12-11 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.92 Å) Cite: CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-LYSIN To Be Published
6SN6	CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-GLUTAMIC ACID Descriptor: CALCIUM ION, Carboxypeptidase T, N-sulfamoyl-L-glutamic acid, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2019-08-23 Release date: 2019-10-09 Method: X-RAY DIFFRACTION (1.93 Å) Cite: CARBOXYPEPTIDASE T WITH N-SULFAMOYL-L-GLUTAMIC ACID To Be Published
6I6Z	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH Descriptor: (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, Carboxypeptidase A1, ZINC ION Authors: Gallego, P, Reverter, D. Deposit date: 2018-11-15 Release date: 2018-12-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes. J. Med. Chem., 62, 2019
6GO2	Carboxypeptidase T with N-sulfamoyl-L-Leucine Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2018-06-01 Release date: 2018-06-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carboxypeptidase T with N-sulfamoyl-L-Leucine To Be Published
6F79	Carboxypeptidase T mutant L211Q with Sulphamoil Arginine Descriptor: CALCIUM ION, Carboxypeptidase T, N~2~-sulfamoyl-L-arginine, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2017-12-07 Release date: 2018-08-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Carboxypeptidase T mutant L211Q with Sulphamoil Arginine To Be Published
6F75	Carboxypeptidase T mutant L254N with Sulphamoil Leucine Descriptor: CALCIUM ION, Carboxypeptidase T, SULFATE ION, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2017-12-07 Release date: 2018-08-15 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Carboxypeptidase T mutant L254N with Sulphamoil Leucine To Be Published
6F6Q	Carboxypeptidase T mutant L254N with Sulphamoil Arginine Descriptor: CALCIUM ION, Carboxypeptidase T, N~2~-sulfamoyl-L-arginine, ... Authors: Timofeev, V.I, Akparov, V.K, Kuranova, I.P. Deposit date: 2017-12-06 Release date: 2018-08-15 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Carboxypeptidase T mutant L254N with Sulphamoil Arginine To Be Published
6CPA	CRYSTAL STRUCTURE OF THE COMPLEX OF CARBOXYPEPTIDASE A WITH A STRONGLY BOUND PHOSPHONATE IN A NEW CRYSTALLINE FORM: COMPARISON WITH STRUCTURES OF OTHER COMPLEXES Descriptor: CARBOXYPEPTIDASE A, O-(((1R)-((N-PHENYLMETHOXYCARBONYL-L-ALANYL)AMINO)ETHYL)HYDROXYPHOSPHONO)-L-BENZYLACETIC ACID, ZINC ION Authors: Kim, H, Lipscomb, W.N. Deposit date: 1990-02-15 Release date: 1991-10-15 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes. Biochemistry, 29, 1990
5ZEQ	Carboxypeptidase B in complex with DD28 Descriptor: (2~{S})-2-[(6-azanyl-5-chloranyl-pyridin-3-yl)methyl]-3-selanyl-propanoic acid, CACODYLATE ION, Carboxypeptidase B, ... Authors: Itoh, T, Yoshimoto, N, Yamamoto, K. Deposit date: 2018-02-27 Release date: 2018-06-20 Last modified: 2018-07-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group Bioorg. Med. Chem. Lett., 28, 2018
5OM9	Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor Descriptor: (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, Carboxypeptidase A1, ZINC ION Authors: Gallego, P, Granados, C, Fernandez, D, Pallares, I, Covaleda, G, Aviles, F.X, Vendrell, J, Reverter, D. Deposit date: 2017-07-28 Release date: 2017-08-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library. ACS Med Chem Lett, 8, 2017
5MRV	Crystal structure of human carboxypeptidase O in complex with NvCI Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase O, Metallocarboxypeptidase inhibitor, ... Authors: Garcia-Pardo, J, Garcia-Guerrero, M.C, Fernandez-Alvarez, R, Lyons, P, Aviles, F.X, Lorenzo, J, Reverter, D. Deposit date: 2016-12-27 Release date: 2018-01-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.854 Å) Cite: Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5LYL	Crystal structure of 1 in complex with tafCPB Descriptor: (2~{S})-2-[[(2~{S})-1-(1-adamantylamino)-3-cyclohexyl-1-oxidanylidene-propan-2-yl]sulfamoylamino]-6-azanyl-hexanoic acid, Carboxypeptidase B, ZINC ION Authors: Schreuder, H, Liesum, A, Loenze, P. Deposit date: 2016-09-28 Release date: 2016-10-26 Last modified: 2016-12-21 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J. Med. Chem., 59, 2016
5LYI	Crystal structure of 1 in complex with tafCPB Descriptor: (2~{S})-6-azanyl-2-[[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(1~{R},2~{S},4~{R})-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl]amino]propan-2-yl]sulfamoylamino]hexanoic acid, Carboxypeptidase B, ZINC ION Authors: Schreuder, H, Liesum, A, Loenze, P. Deposit date: 2016-09-28 Release date: 2016-10-26 Last modified: 2016-12-21 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). J. Med. Chem., 59, 2016

 

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