8QTT
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8QTF
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8QTC
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8QT5
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8Q4L
| GBP1 bound by 14-3-3sigma | Descriptor: | 14-3-3 protein sigma, Guanylate-binding protein 1 | Authors: | Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. | Deposit date: | 2023-08-07 | Release date: | 2023-10-11 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (5.12 Å) | Cite: | PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
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8Q1S
| Pathogenic mutations of human phosphorylation sites affect protein-protein interactions | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... | Authors: | Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. | Deposit date: | 2023-08-01 | Release date: | 2024-02-21 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (3.23 Å) | Cite: | Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
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8P1H
| Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor | Descriptor: | 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... | Authors: | Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. | Deposit date: | 2023-05-12 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
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8P0D
| Human 14-3-3 sigma in complex with human MDM2 peptide | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. | Deposit date: | 2023-05-10 | Release date: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
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8HEW
| Potato 14-3-3 St14f | Descriptor: | 14-3-3 protein, StFDL1 peptide | Authors: | Taoka, K, Kawahara, I, Shinya, S, Harada, K, Muranaka, T, Furuita, K, Nakagawa, A, Fujiwara, T, Tsuji, H, Kojima, C. | Deposit date: | 2022-11-08 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Multifunctional chemical inhibitors of the florigen activation complex discovered by structure-based high-throughput screening. Plant J., 112, 2022
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8EQH
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8EQ8
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8DP5
| Structure of the PEAK3/14-3-3 complex | Descriptor: | 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... | Authors: | Torosyan, H, Paul, M, Jura, N, Verba, K.A. | Deposit date: | 2022-07-14 | Release date: | 2023-06-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
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8DGT
| Cryo-EM structure of a RAS/RAF complex (state 2) | Descriptor: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Eck, M.J, Jeon, H, Park, E, Rawson, S. | Deposit date: | 2022-06-24 | Release date: | 2023-07-05 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
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8DGS
| Cryo-EM structure of a RAS/RAF complex (state 1) | Descriptor: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Eck, M.J, Jeon, H, Park, E, Rawson, S. | Deposit date: | 2022-06-24 | Release date: | 2023-07-05 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of a RAS/RAF recruitment complex. Nat Commun, 14, 2023
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8DGP
| 14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Phosphorylated PEAK3 (pS69) peptide, ... | Authors: | Roy, M.J, Hardy, J.M, Lucet, I.S. | Deposit date: | 2022-06-24 | Release date: | 2023-06-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
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8DGN
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8DGM
| 14-3-3 epsilon bound to phosphorylated PEAK1 (pT1165) peptide | Descriptor: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, Inactive tyrosine-protein kinase PEAK1 | Authors: | Roy, M.J, Hardy, J.M, Lucet, I.S. | Deposit date: | 2022-06-24 | Release date: | 2023-06-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
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8C4G
| Small molecule amidine soak in 14-3-3/ERa (AZ132) | Descriptor: | 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... | Authors: | Visser, E.J, Sijbesma, E, Ottmann, C. | Deposit date: | 2023-01-03 | Release date: | 2023-08-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8C4F
| Small molecule amidine soak in 14-3-3/ERa (AZ037) | Descriptor: | 14-3-3 protein sigma, 5-(cyclohexylamino)-4-phenyl-thiophene-2-carboximidamide, ERalpha peptide, ... | Authors: | Visser, E.J, Sijbesma, E, Ottmann, C. | Deposit date: | 2023-01-03 | Release date: | 2023-08-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew.Chem.Int.Ed.Engl., 62, 2023
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8C43
| Ternary structure of 14-3-3sigma, strep-tagged PKA-responsive ERa phosphopeptide, and Fusicoccin-A. | Descriptor: | 14-3-3 protein sigma, De-acetylated Fusicoccin, Estrogen Receptor alpha phosphopeptide, ... | Authors: | Somsen, B.A, Ottmann, C. | Deposit date: | 2022-12-30 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
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8C42
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8C40
| 14-3-3sigma bound to PKA-responsive ERa phosphopeptide | Descriptor: | 14-3-3 protein sigma, Estrogen Receptor alpha phosphopeptide, MAGNESIUM ION | Authors: | Somsen, B.A, Ottmann, C. | Deposit date: | 2022-12-30 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Molecular basis and dual ligand regulation of tetrameric estrogen receptor alpha /14-3-3 zeta protein complex. J.Biol.Chem., 299, 2023
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8C3Z
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8C3C
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8C30
| Crystal structure of 14-3-3 in complex with PyrinpS242 and a protein/peptide interface fragment | Descriptor: | 14-3-3 protein sigma, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, CALCIUM ION, ... | Authors: | Lau, R, Ottmann, C. | Deposit date: | 2022-12-23 | Release date: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | 14-3-3/Pyrin complex To Be Published
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