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6AO9	Crystal structure of monomeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
4WP9	Crystal structure of Adenylyl cyclase MA1120 from Mycobacterium Avium bound to 2'5'-DD-3'-ATP, Calcium and Magnesium ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CALCIUM ION, MAGNESIUM ION, ... Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.382 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
6AOA	Monomeric crystal structure of the E497/C566D double mutant of the guanylyl cyclase domain of the RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
7R65	Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29 Descriptor: Adenylate/guanylate cyclase Authors: Morehouse, B.R, Kranzusch, P.J. Deposit date: 2021-06-22 Release date: 2021-10-13 Last modified: 2021-11-24 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell, 184, 2021
1FX2	STRUCTURAL ANALYSIS OF ADENYLATE CYCLASES FROM TRYPANOSOMA BRUCEI IN THEIR MONOMERIC STATE Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, RECEPTOR-TYPE ADENYLATE CYCLASE GRESAG 4.1, SULFATE ION Authors: Bieger, B, Essen, L.-O. Deposit date: 2000-09-25 Release date: 2001-02-28 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Structural analysis of adenylate cyclases from Trypanosoma brucei in their monomeric state. EMBO J., 20, 2001
3R5G	Crystal structure of the adenylyl cyclase CyaB from P. aeruginosa Descriptor: CyaB, GLYCEROL Authors: Topal, H, Steegborn, C. Deposit date: 2011-03-18 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosa. J.Mol.Biol., 416, 2012
8QFE	Cryogenic crystal structure of the Photoactivated Adenylate Cyclase OaPAC Descriptor: FLAVIN MONONUCLEOTIDE, Family 3 adenylate cyclase, MAGNESIUM ION Authors: Chretien, A, Nagel, M.F, Botha, S, de Wijn, R, Brings, L, Doerner, K, Han, H, Koliyadu, J, Letrun, R, Round, A, Sato, T, Schmidt, C, Secareanu, R, von Stetten, D, Vakili, M, Wrona, A, Bean, R, Mancuso, A, Schulz, J, Pearson, A, Kottke, T, Lorenzen, K, Schubert, R. Deposit date: 2023-09-04 Release date: 2023-11-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Light-induced Trp in /Met out Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC. J.Mol.Biol., 436, 2024
5X4T	PAC from Oscillatoria acuminata after 20 seconds photoactivation Descriptor: FLAVIN MONONUCLEOTIDE, Photoactivated adenylyl cyclase Authors: Ohki, M, Park, S.-Y. Deposit date: 2017-02-14 Release date: 2017-07-26 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Molecular mechanism of photoactivation of a light-regulated adenylate cyclase. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
2WZ1	STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN SOLUBLE GUANYLATE CYCLASE 1 BETA 3. Descriptor: 1,2-ETHANEDIOL, GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 Authors: Allerston, C.K, Cooper, C.D.O, Muniz, J, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Gileadi, O. Deposit date: 2009-11-23 Release date: 2009-12-01 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase. Plos One, 8, 2013
4WP8	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium in complex with 2'5'-DD-3'-ATP and Manganese ion Descriptor: 2',5'-dideoxyadenosine 3'-(tetrahydrogen triphosphate), CHLORIDE ION, MANGANESE (II) ION, ... Authors: Barathy, D.V, Bharambe, N.G, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
6SIR	Crystal structure of the guanylate cyclase domain of RhGC from Catenaria anguillulae in complex with GTP Descriptor: CALCIUM ION, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Butryn, A, Orville, A.M. Deposit date: 2019-08-10 Release date: 2019-12-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular basis for GTP recognition by light-activated guanylate cyclase RhGC. Febs J., 287, 2020
4CLL	Crystal structure of human soluble Adenylyl Cyclase in complex with bicarbonate Descriptor: 1,2-ETHANEDIOL, ADENYLATE CYCLASE TYPE 10, BICARBONATE ION, ... Authors: Kleinboelting, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-15 Release date: 2014-03-05 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4OYI	Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone Descriptor: (4-azanyl-1,2,5-oxadiazol-3-yl)-phenyl-methanone, Adenylate cyclase type 10, GLYCEROL Authors: Vinkovic, M. Deposit date: 2014-02-12 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYW	Crystal Structure of Human Soluble Adenylate Cyclase Descriptor: Adenylate cyclase type 10, CHLORIDE ION, GLYCEROL Authors: Vinkovic, M. Deposit date: 2014-02-13 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYM	Human solAC Complexed with (4-Amino-furazan-3-yl)-(3-methoxy-phenyl)-methanone Descriptor: (4-azanyl-1,2,5-oxadiazol-3-yl)-(3-methoxyphenyl)methanone, Adenylate cyclase type 10, GLYCEROL Authors: Vinkovic, M. Deposit date: 2014-02-12 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4WPA	Crystal structure of Adenylyl cyclase Ma1120 from Mycobacterium Avium bound to Pyrophosphate and Calcium Descriptor: CALCIUM ION, Ma1120, PYROPHOSPHATE Authors: Bharambe, N.G, Barathy, D.V, Suguna, K. Deposit date: 2014-10-17 Release date: 2015-09-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase J.Struct.Biol., 190, 2015
4OYB	Crystal Structure Analysis of the solAC Descriptor: Adenylate cyclase type 10, GLYCEROL, ethyl 2-[3-[(4-azanyl-1,2,5-oxadiazol-3-yl)carbonyl]phenoxy]ethanoate Authors: Vinkovic, M. Deposit date: 2014-02-11 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OZ3	Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole Descriptor: 4-phenyl-3-(trifluoromethyl)-1H-pyrazole, Adenylate cyclase type 10, GLYCEROL Authors: Vinkovic, M. Deposit date: 2014-02-13 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
8QFG	Cryogenic crystal structure of the Photoactivated Adenylate Cyclase OaPAC after 5 seconds of blue light illumination Descriptor: ADENOSINE-5'-TRIPHOSPHATE, FLAVIN MONONUCLEOTIDE, Family 3 adenylate cyclase, ... Authors: Chretien, A, Nagel, M.F, Botha, S, de Wijn, R, Brings, L, Doerner, K, Han, H, C.P.Koliyadu, J, Letrun, R, Round, A, Sato, T, Schmidt, C, Secareanu, R, von Stetten, D, Vakili, M, Wrona, A, Bean, R, Mancuso, A, Schulz, J, R.Pearson, A, Kottke, T, Lorenzen, K, Schubert, R. Deposit date: 2023-09-04 Release date: 2023-11-01 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Light-induced Trp in /Met out Switching During BLUF Domain Activation in ATP-bound Photoactivatable Adenylate Cyclase OaPAC. J.Mol.Biol., 436, 2024
6AOB	Crystal structure of non-canonical dimeric guanylyl cyclase domain of RhoGC fusion protein from the aquatic fungus Blastocladiella emersonii Descriptor: Bacterio-rhodopsin/guanylyl cyclase 1 fusion protein, L(+)-TARTARIC ACID, MANGANESE (II) ION Authors: Prem Kumar, R, Oprian, D.D. Deposit date: 2017-08-15 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC. J. Biol. Chem., 292, 2017
4CLF	Crystal structure of human soluble Adenylyl Cyclase (Apo form) Descriptor: ACETATE ION, ADENYLATE CYCLASE TYPE 10, GLYCEROL Authors: Kleinboelting, S, Moniot, S, Weyand, M, Steegborn, C. Deposit date: 2014-01-14 Release date: 2014-03-05 Last modified: 2019-04-03 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structures of Human Soluble Adenylyl Cyclase Reveal Mechanisms of Catalysis and of its Activation Through Bicarbonate. Proc.Natl.Acad.Sci.USA, 111, 2014
4OYZ	Human solAC Complexed with Bicarbonate Descriptor: Adenylate cyclase type 10, BICARBONATE ION, GLYCEROL Authors: Vinkovic, M. Deposit date: 2014-02-13 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
4OYO	Human solAC Complexed with 4-(2-Chlorophenyl)-3-methyl-1H-pyrazole Descriptor: 4-(2-chlorophenyl)-5-methyl-1H-pyrazole, Adenylate cyclase type 10, GLYCEROL Authors: Vinkovic, M. Deposit date: 2014-02-12 Release date: 2014-04-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal structure of human soluble adenylate cyclase reveals a distinct, highly flexible allosteric bicarbonate binding pocket. Chemmedchem, 9, 2014
5IV4	Crystal structure of the human soluble adenylyl cyclase in complex with the allosteric inhibitor LRE1 Descriptor: 1,2-ETHANEDIOL, 6-chloro-N~4~-cyclopropyl-N~4~-[(thiophen-2-yl)methyl]pyrimidine-2,4-diamine, ACETATE ION, ... Authors: Kleinboelting, S, Steegborn, C. Deposit date: 2016-03-18 Release date: 2016-08-17 Last modified: 2022-11-30 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat.Chem.Biol., 12, 2016
4YUS	Crystal structure of photoactivated adenylyl cyclase of a cyanobacteriaOscillatoria acuminata in hexagonal form Descriptor: FLAVIN MONONUCLEOTIDE, Family 3 adenylate cyclase Authors: Park, S.-Y, Ohki, M, Sugiyama, K, Kawai, F, Iseki, M. Deposit date: 2015-03-19 Release date: 2016-06-01 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium Proc.Natl.Acad.Sci.USA, 113, 2016

 

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