6G3D
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CRYSTAL STRUCTURE OF NATIVE EDDS LYASE
Descriptor:Argininosuccinate lyase
Authors:Poddar, H., Thunnissem, A.M.W.H., Poelarends, G.J.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.221 Å)
Cite:Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.
Biochemistry, 57, 2018
6G3E
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CRYSTAL STRUCTURE OF EDDS LYASE IN COMPLEX WITH FORMATE
Descriptor:Argininosuccinate lyase, FORMIC ACID, SODIUM ION
Authors:Poddar, H., Thunnissem, A.M.W.H., Poelarends, G.J.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.
Biochemistry, 57, 2018
6G3F
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CRYSTAL STRUCTURE OF EDDS LYASE IN COMPLEX WITH FUMARATE
Descriptor:Argininosuccinate lyase, FUMARIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Poddar, H., Thunnissem, A.M.W.H., Poelarends, G.J.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.222 Å)
Cite:Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.
Biochemistry, 57, 2018
6G3G
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CRYSTAL STRUCTURE OF EDDS LYASE IN COMPLEX WITH SUCCINATE
Descriptor:Argininosuccinate lyase, SUCCINIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Poddar, H., Thunnissem, A.M.W.H., Poelarends, G.J.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.606 Å)
Cite:Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.
Biochemistry, 57, 2018
6G3H
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CRYSTAL STRUCTURE OF EDDS LYASE IN COMPLEX WITH SS-EDDS
Descriptor:Argininosuccinate lyase, (2~{S})-2-[2-[[(2~{S})-1,4-bis(oxidanyl)-1,4-bis(oxidanylidene)butan-2-yl]amino]ethylamino]butanedioic acid
Authors:Poddar, H., Thunnissem, A.M.W.H., Poelarends, G.J.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.269 Å)
Cite:Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.
Biochemistry, 57, 2018
6G3I
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CRYSTAL STRUCTURE OF EDDS LYASE IN COMPLEX WITH N-(2-AMINOETHYL)ASPARTIC ACID (AEAA)
Descriptor:Argininosuccinate lyase, (2~{S})-2-(2-azanylethylamino)butanedioic acid, FUMARIC ACID
Authors:Poddar, H., Thunnissem, A.M.W.H., Poelarends, G.J.
Deposit date:2018-03-25
Release date:2018-05-16
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.
Biochemistry, 57, 2018
5XNY
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CRYSTAL STRUCTURE OF CRED
Descriptor:CreD
Authors:Katsuyama, Y., Sato, Y., Sugai, Y., Higashiyama, Y., Senda, M., Senda, T., Ohnishi, Y.
Deposit date:2017-05-25
Release date:2018-03-14
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal structure of the nitrosuccinate lyase CreD in complex with fumarate provides insights into the catalytic mechanism for nitrous acid elimination
FEBS J., 285, 2018
5XNZ
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CRYSTAL STRUCTURE OF CRED COMPLEX WITH FUMARATE
Descriptor:CreD, FUMARIC ACID
Authors:Katsuyama, Y., Sato, Y., Sugai, Y., Higashiyama, Y., Senda, M., Senda, T., Ohnishi, Y.
Deposit date:2017-05-25
Release date:2018-03-14
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the nitrosuccinate lyase CreD in complex with fumarate provides insights into the catalytic mechanism for nitrous acid elimination
FEBS J., 285, 2018
5UPP
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CRYSTAL STRUCTURE OF HUMAN FUMARATE HYDRATASE
Descriptor:Fumarate hydratase, mitochondrial, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Rangel, V.L., Ajalla, M.A., Rustiguel, J.K., Pereira de Padua, R.A., Nonato, M.C.
Deposit date:2017-02-03
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human fumarate hydratase
To Be Published
5V4L
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CRYPTOCOCCUS NEOFORMANS ADENYLOSUCCINATE LYASE
Descriptor:Adenylosuccinate lyase
Authors:Chitty, J., Williams, S.J., Kobe, B., Fraser, J.A.
Deposit date:2017-03-09
Release date:2017-06-07
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.
J. Biol. Chem., 292, 2017
5VKW
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE ADE13 FROM CANDIDA ALBICANS
Descriptor:Adenylosuccinate lyase, CHLORIDE ION, GLYCEROL, ...
Authors:Stogios, P.J., Evdokimova, E., Di Leo, R., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-04-24
Release date:2017-05-24
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Crystal structure of adenylosuccinate lyase ADE13 from Candida albicans
To Be Published
5EYT
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM SCHISTOSOMA MANSONI IN COMPLEX WITH AMP
Descriptor:Adenylosuccinate lyase, ADENOSINE MONOPHOSPHATE
Authors:Romanello, L., Torini, J.R., Bird, L., Nettleship, J., Owens, R., Reddivari, Y., Brandao-Neto, J., Pereira, H.M.
Deposit date:2015-11-25
Release date:2016-11-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3649 Å)
Cite:Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL).
Mol. Biochem. Parasitol., 214, 2017
5EYV
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM SCHISTOSOMA MANSONI IN APO FORM.
Descriptor:Adenylosuccinate lyase
Authors:Romanello, L., Torini, J.R., Bird, L.E., Nettleship, J.E., Owens, R.J., Reddivari, Y., Brandao-Neto, J., Pereira, H.M.
Deposit date:2015-11-25
Release date:2016-11-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase (SmADSL).
Mol. Biochem. Parasitol., 214, 2017
5E3V
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TRUNCATED X-RAY CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM SALMONELLA TYPHIMURIUM
Descriptor:Adenylosuccinate lyase
Authors:Banerjee, S., Agrawal, M.J., Murthy, M.R.N.
Deposit date:2015-10-04
Release date:2016-10-05
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystallographic and kinetic studies on Adenylosuccinate Lyase from Salmonella typhimurium
To Be Published
5D6B
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HUMAN FUMARASE (WILD TYPE)
Descriptor:Fumarate hydratase, mitochondrial
Authors:Pereira de Padua, R.A., Nonato, M.C.
Deposit date:2015-08-11
Release date:2016-08-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase.
Acta Crystallogr F Struct Biol Commun, 70, 2014
5F91
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FUMARATE HYDRATASE OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH FORMATE AND ALLOSTERIC MODULATOR (N-(5-(AZEPAN-1-YLSULFONYL)-2-METHOXYPHENYL)-2-(4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETAMIDE)
Descriptor:Fumarate hydratase class II, ~{N}-[5-(azepan-1-ylsulfonyl)-2-methoxy-phenyl]-2-(4-oxidanylidene-3~{H}-phthalazin-1-yl)ethanamide, CHLORIDE ION, ...
Authors:Kasbekar, M., Fischer, G., Mott, B.T., Yasgar, A., Hyvonen, M., Boshoff, H.I., Abell, C., Barry, C.E., Thomas, C.J.
Deposit date:2015-12-09
Release date:2016-06-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc.Natl.Acad.Sci.USA, 113, 2016
5F92
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FUMARATE HYDRATASE OF MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH FORMATE
Descriptor:Fumarate hydratase class II, FORMIC ACID, CHLORIDE ION, ...
Authors:Kasbekar, M., Fischer, G., Mott, B.T., Yasgar, A., Hyvonen, M., Boshoff, H.I., Abell, C., Barry, C.E., Thomas, C.J.
Deposit date:2015-12-09
Release date:2016-06-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.859 Å)
Cite:Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HW2
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM FRANCISELLA TULARENSIS COMPLEXED WITH FUMARIC ACID
Descriptor:Adenylosuccinate lyase, POTASSIUM ION, FUMARIC ACID, ...
Authors:Chang, C., Maltseva, N., Kim, Y., Shatsman, S., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-01-28
Release date:2016-02-10
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Crystal Structure of Adenylosuccinate Lyase from Francisella tularensis Complexed with fumaric acid
To Be Published
4NSL
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X-RAY CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM SALMONELLA TYPHIMURIUM
Descriptor:Adenylosuccinate lyase, PENTANE-1,5-DIAMINE
Authors:Banerjee, S., Agrawal, M.J., Murthy, M.R.N.
Deposit date:2013-11-28
Release date:2014-12-03
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic and kinetic studies on Adenylosuccinate Lyase from Salmonella typhimurium
To be Published
4MX2
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM LEISHMANIA DONOVANI
Descriptor:Adenylosuccinate lyase, ADENOSINE MONOPHOSPHATE, SULFATE ION, ...
Authors:Wernimont, A.K., Loppnau, P., Dong, A., Krojer, T., Bradley, A., Bushell, S., von Delft, F., Robinson, D., Gilbert, I., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Hui, R., Mottaghi, K., Structural Genomics Consortium (SGC)
Deposit date:2013-09-25
Release date:2014-04-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of adenylosuccinate lyase from Leishmania donovani
To be Published
4NLE
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CRYSTAL STRUCTURE OF APO ADENYLOSUCCINATE LYASE FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Adenylosuccinate lyase
Authors:Banerjee, S., Murthy, M.R.N.
Deposit date:2013-11-14
Release date:2014-03-05
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural and kinetic studies on Adenylosuccinate Lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme
Febs J., 2014
4EFC
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM TRYPANOSOMA BRUCEI, TB427TMP.160.5560
Descriptor:Adenylosuccinate lyase, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
Authors:Wernimont, A.K., Loppnau, P., Osman, K.T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Robinson, D.A., Wyatt, P.G., Gilbert, I.H., Fairlamb, A.H., Hui, R., Lin, Y.H., Structural Genomics Consortium (SGC)
Deposit date:2012-03-29
Release date:2013-02-13
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Adenylosuccinate Lyase from Trypanosoma Brucei, Tb427tmp.160.5560
To be Published
4HGV
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CRYSTAL STRUCTURE OF A FUMARATE HYDRATASE
Descriptor:Fumarate hydratase class II, SULFATE ION
Authors:Eswaramoorthy, S., Evans, B., Foti, R., Gizzi, A., Hillerich, B., Kar, A., Lafleur, J., Seidel, R., Villigas, G., Zencheck, W., Almo, S.C., Swaminathan, S., New York Structural Genomics Research Consortium (NYSGRC)
Deposit date:2012-10-08
Release date:2012-10-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of a fumarate hydratase
To be Published
4FFX
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMAN ADENYLOSUCCINATE LYASE (ADSL) AND THE R303C ADSL DEFICIENCY ASSOCIATED MUTATION
Descriptor:Adenylosuccinate lyase
Authors:Deaton, M.K., Ray, S.P., Capodagli, G.C., Calkins, L.A.F., Sawle, L., Ghosh, K., Patterson, D., Pegan, S.D.
Deposit date:2012-06-01
Release date:2012-08-01
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.
Biochemistry, 51, 2012
4FLC
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMAN ADENYLOSUCCINATE LYASE (ADSL) AND THE R303C ADSL DEFICIENCY ASSOCIATED MUTATION
Descriptor:Adenylosuccinate lyase
Authors:Deaton, M.K., Ray, S.P., Capodagli, G.C., Calkins, L.A.F., Sawle, L., Ghosh, K., Patterson, D., Pegan, S.D.
Deposit date:2012-06-14
Release date:2012-08-01
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.
Biochemistry, 51, 2012
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