6GDZ
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EXENDIN-4 BASED DUAL GLP-1/GLUCAGON RECEPTOR AGONIST
Descriptor:Exendin-4, (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid
Authors:Evers, A., Kurz, M.
Deposit date:2018-04-25
Release date:2018-06-20
Last modified:2018-07-25
Method:SOLUTION NMR
Cite:Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
6GE2
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EXENDIN-4 BASED DUAL GLP-1/GLUCAGON RECEPTOR AGONIST
Descriptor:Exendin-4, (2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid
Authors:Evers, A., Kurz, M.
Deposit date:2018-04-25
Release date:2018-06-20
Last modified:2018-07-25
Method:SOLUTION NMR
Cite:Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
J. Med. Chem., 61, 2018
5OTT
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EXTRACELLULAR DOMAIN OF GLP-1 RECEPTOR IN COMPLEX WITH EXENDIN-4 VARIANT GLY2HCS/THR5HCS
Descriptor:Glucagon-like peptide 1 receptor, Exendin-4
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTU
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EXTRACELLULAR DOMAIN OF GLP-1 RECEPTOR IN COMPLEX WITH GLP-1 VARIANT ALA8HCS/THR11HCS
Descriptor:Glucagon-like peptide 1 receptor, Glucagon
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTV
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EXTRACELLULAR DOMAIN OF GLP-1 RECEPTOR IN COMPLEX WITH GLP-1 VARIANT ALA8CYC/THR11HCS
Descriptor:Glucagon-like peptide 1 receptor, Glucagon
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTW
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EXTRACELLULAR DOMAIN OF GLP-1 RECEPTOR IN COMPLEX WITH GLP-1 VARIANT ALA8HCS/THR11CYS
Descriptor:Glucagon-like peptide 1 receptor, Glucagon
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5OTX
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EXTRACELLULAR DOMAIN OF GLP-1 RECEPTOR IN COMPLEX WITH GLP-1 VARIANT ALA8CYS/THR11CYS
Descriptor:Glucagon-like peptide 1 receptor, Glucagon
Authors:Mortensen, S.
Deposit date:2017-08-22
Release date:2018-07-04
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:alpha-Helix or beta-Turn? An Investigation into N-Terminally Constrained Analogues of Glucagon-like Peptide 1 (GLP-1) and Exendin-4.
Biochemistry, 57, 2018
5VAI
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CRYO-EM STRUCTURE OF THE ACTIVATED GLUCAGON-LIKE PEPTIDE-1 RECEPTOR IN COMPLEX WITH G PROTEIN
Descriptor:Uncharacterized protein, Glucagon-like peptide 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Zhang, Y., Sun, B., Feng, D., Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Kobilka, T.S., Kobilka, B.K., Skiniotis, G.
Deposit date:2017-03-27
Release date:2017-05-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
5NIQ
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EXENDIN-4 VARIANT WITH DUAL GLP-1 / GLUCAGON RECEPTOR ACTIVITY
Descriptor:Exendin-4, N-hexadecanoyl-L-glutamic acid
Authors:Evers, A., Kurz, M.
Deposit date:2017-03-24
Release date:2018-02-28
Method:SOLUTION NMR
Cite:exendin-4 variant with dual GLP-1 / glucagon receptor activity
To Be Published
5BQM
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CRYSTAL STRUCTURE OF SXN101959, A CLOSTRIDIUM BOTULINUM NEUROTOXIN TYPE D DERIVATIVE AND TARGETED SECRETION INHIBITOR
Descriptor:Botulinum neurotoxin type D, Somatoliberin,Botulinum neurotoxin type D, ZINC ION
Authors:Masuyer, G., Davies, J.R., Moore, K., Chaddock, J.A., Acharya, K.R.
Deposit date:2015-05-29
Release date:2015-08-19
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.
Sci Rep, 5, 2015
4ZGM
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CRYSTAL STRUCTURE OF SEMAGLUTIDE PEPTIDE BACKBONE IN COMPLEX WITH THE GLP-1 RECEPTOR EXTRACELLULAR DOMAIN
Descriptor:Glucagon-like peptide 1 receptor, Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH, 3,6,9,12,15,18-hexaoxahexacosan-1-ol
Authors:Reedtz-Runge, S.
Deposit date:2015-04-23
Release date:2015-09-09
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
J.Med.Chem., 58, 2015
2MJ9
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DESIGNED EXENDIN-4 ANALOGUES
Descriptor:Exendin-4
Authors:Rovo, P., Farkas, V., Straner, P., Szabo, M., Jermendy, A., Hegyi, O., Toth, G.K., Perczel, A.
Deposit date:2013-12-30
Release date:2014-06-04
Method:SOLUTION NMR
Cite:Rational design of alpha-helix stabilized Exendin-4 analogues.
Biochemistry, 2014
2M5Q
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SOLUTION STRUCTURE OF LIPIDATED GLUCAGON ANALOG IN D-TFE
Descriptor:Glucagon, GAMMA-L-GLUTAMIC ACID, PALMITIC ACID
Authors:Ward, B.P., Ma, D.
Deposit date:2013-03-04
Release date:2013-03-27
Method:SOLUTION NMR
Cite:Structural Changes Associated with Peptide Lipidation Broaden Biological Function
To be Published
2M5P
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SOLUTION STRUCTURE OF LIPIDATED GLUCAGON ANALOG IN WATER
Descriptor:Glucagon, GAMMA-L-GLUTAMIC ACID, PALMITIC ACID
Authors:Ward, B.P., Ma, D.
Deposit date:2013-03-03
Release date:2013-03-27
Method:SOLUTION NMR
Cite:Structural Changes Associated with Peptide Lipidation Broaden Biological Function
To be Published
4APD
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LIRAGLUTIDE
Descriptor:LIRAGLUTIDE, N-hexadecanoyl-L-glutamic acid
Authors:Ludvigsen, S., Steensgaard, D.B., Thomsen, J.K., Strauss, H., Normann, M.
Deposit date:2012-04-02
Release date:2013-07-10
Last modified:2014-01-29
Method:SOLUTION NMR
Cite:Liraglutide
To be Published
2RRI
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NMR STRUCTURE OF VASOACTIVE INTESTINAL PEPTIDE IN DPC MICELLE
Descriptor:Vasoactive intestinal peptide
Authors:Umetsu, Y., Tenno, T., Goda, N., Shirakawa, M., Ikegami, T., Hiroaki, H.
Deposit date:2010-12-21
Release date:2011-04-06
Last modified:2011-12-28
Method:SOLUTION NMR
Cite:Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments
Biochim.Biophys.Acta, 1814, 2011
2L70
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NMR SOLUTION STRUCTURE OF GIP IN MICELLULAR MEDIA
Descriptor:Gastric inhibitory polypeptide
Authors:Venneti, K.C., Alana, I., O'Harte, F.P.M., Malthouse, P.J.G., Hewage, C.M.
Deposit date:2010-12-01
Release date:2011-10-19
Method:SOLUTION NMR
Cite:Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide
Biochim.Biophys.Acta, 1814, 2011
2L71
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NMR SOLUTION STRUCTURE OF GIP IN BICELLULAR MEDIA
Descriptor:Gastric inhibitory polypeptide
Authors:Venneti, K.C., Alana, I., O'Harte, F.P.M., Malthouse, P.J.G., Hewage, C.M.
Deposit date:2010-12-01
Release date:2011-10-19
Method:SOLUTION NMR
Cite:Conformational, receptor interaction and alanine scan studies of glucose-dependent insulinotropic polypeptide
Biochim.Biophys.Acta, 1814, 2011
2L63
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NMR SOLUTION STRUCTURE OF GLP-2 IN 2,2,2 TRIFLUROETHANOL
Descriptor:Glucagon-like peptide 2
Authors:Venneti, K.C., Hewage, C.M.
Deposit date:2010-11-12
Release date:2011-02-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.
Febs Lett., 585, 2011
2L64
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NMR SOLUTION STRUCTURE OF GLP-2 IN DHPC MICELLES
Descriptor:Glucagon-like peptide 2
Authors:Venneti, K.C., Hewage, C.M.
Deposit date:2010-11-12
Release date:2011-02-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.
Febs Lett., 585, 2011
2RRH
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NMR STRUCTURE OF VASOACTIVE INTESTINAL PEPTIDE IN METHANOL
Descriptor:VIP peptides
Authors:Umetsu, Y., Tenno, T., Goda, N., Ikegami, T., Hiroaki, H.
Deposit date:2010-11-12
Release date:2011-04-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural difference of vasoactive intestinal peptide in two distinct membrane mimicking environments
Biochem.Biophys.Acta Proteins & Proteomics, 2011
3IOL
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CRYSTAL STRUCTURE OF GLUCAGON-LIKE PEPTIDE-1 IN COMPLEX WITH THE EXTRACELLULAR DOMAIN OF THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR
Descriptor:Glucagon-like peptide 1 receptor, Glucagon, decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside
Authors:Reedtz-Runge, S.
Deposit date:2009-08-14
Release date:2009-10-27
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor
J.Biol.Chem., 285, 2010
2QKH
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GIP RECEPTOR IN COMPLEX WITH THE HORMONE GIP
Descriptor:Glucose-dependent insulinotropic polypeptide, Glucose-dependent insulinotropic polypeptide receptor, Methyl-cyclo-hepta-amylose, ...
Authors:Parthier, C., Kleinschmidt, M., Neumann, P., Rudolph, R., Manhart, S., Schlenzig, D., Fanghanel, J., Rahfeld, J.-U., Demuth, H.-U., Stubbs, M.T.
Deposit date:2007-07-11
Release date:2007-08-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OBU
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SOLUTION STRUCTURE OF GIP IN TFE/WATER
Descriptor:Gastric inhibitory polypeptide
Authors:Alana, I., Malthouse, J.P.G., O'Harte, F.P.M., Hewage, C.M.
Deposit date:2006-12-20
Release date:2007-06-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy
Proteins, 68, 2007
2G49
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH GLUCAGON
Descriptor:Insulin-degrading enzyme, glucagon preproprotein, 1,4-DIETHYLENE DIOXIDE
Authors:Shen, Y., Tang, W.-J.
Deposit date:2006-02-21
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
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