5BQM

Crystal structure of SXN101959, a Clostridium botulinum neurotoxin type D derivative and targeted secretion inhibitor

Summary for 5BQM

Entry DOI	10.2210/pdb5bqm/pdb
Descriptor	Botulinum neurotoxin type D, Somatoliberin,Botulinum neurotoxin type D, ZINC ION, ... (4 entities in total)
Functional Keywords	botulinum neurotoxin, targeted secretion inhibitors, endopeptidase, type d, protein engineering, hydrolase
Biological source	Clostridium botulinum More
Cellular location	Botulinum neurotoxin D light chain: Secreted. Botulinum neurotoxin D heavy chain: Secreted: P19321 P19321
Total number of polymer chains	4
Total formula weight	210922.22
Authors	Masuyer, G.,Davies, J.R.,Moore, K.,Chaddock, J.A.,Acharya, K.R. (deposition date: 2015-05-29, release date: 2015-08-19, Last modification date: 2024-01-10)
Primary citation	Masuyer, G.,Davies, J.R.,Moore, K.,Chaddock, J.A.,Ravi Acharya, K. Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors. Sci Rep, 5:13397-13397, 2015 Cited by PubMed: 26324071 DOI: 10.1038/srep13397 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation