5BQM
Crystal structure of SXN101959, a Clostridium botulinum neurotoxin type D derivative and targeted secretion inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0005179 | molecular_function | hormone activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0008320 | molecular_function | protein transmembrane transporter activity |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0005179 | molecular_function | hormone activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0008320 | molecular_function | protein transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1000 |
| Chain | Residue |
| A | HIS229 |
| A | HIS233 |
| A | GLU269 |
| A | HOH1102 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN C 1000 |
| Chain | Residue |
| C | HIS229 |
| C | HIS233 |
| C | GLU269 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. ALMHELTHSL |
| Chain | Residue | Details |
| A | ALA226-LEU235 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16519520","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26324071","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FPQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BQM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
