5BQM

Crystal structure of SXN101959, a Clostridium botulinum neurotoxin type D derivative and targeted secretion inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
B	0008320	molecular_function	protein transmembrane transporter activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008270	molecular_function	zinc ion binding
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
D	0008320	molecular_function	protein transmembrane transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1000

Chain	Residue
A	HIS229
A	HIS233
A	GLU269
A	HOH1102

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN C 1000

Chain	Residue
C	HIS229
C	HIS233
C	GLU269

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. ALMHELTHSL

Chain	Residue	Details
A	ALA226-LEU235

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU230
C	GLU230

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16519520, ECO:0000269|PubMed:26324071, ECO:0007744|PDB:2FPQ, ECO:0007744|PDB:5BQM

Chain	Residue	Details
A	HIS229
A	HIS233
A	GLU269
C	HIS229
C	HIS233
C	GLU269

---