6ZRV
| Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93) | Descriptor: | Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93) | Authors: | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2020-07-15 | Release date: | 2020-08-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity. Int J Mol Sci, 21, 2020
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7VLJ
| Crystal structure of Entamoeba histolytica serine protease inhibitor, Histopin, in the cleaved conformation | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, POTASSIUM ION, ... | Authors: | Ali, M.F, Devi, S, Gourinath, S. | Deposit date: | 2021-10-03 | Release date: | 2021-11-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Crystal structure of Entamoeba histolytica serine protease inhibitor, Histopin, in the cleaved conformation To Be Published
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9PAI
| CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Descriptor: | PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364, PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 365-397 | Authors: | Aertgeerts, K, De Bondt, H.L, De Ranter, C.J, Declerck, P.J. | Deposit date: | 1999-03-11 | Release date: | 1999-03-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1. Nat.Struct.Biol., 2, 1995
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9API
| THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA 1-ANTITRYPSIN, ... | Authors: | Loebermann, H, Tokuoka, R, Deisenhofer, J, Huber, R. | Deposit date: | 1988-09-08 | Release date: | 1990-10-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism. Protein Eng., 2, 1989
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6ROD
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6SSV
| The structure of serpin from Schistosoma mansoni | Descriptor: | Serpin, putative | Authors: | De Benedetti, S, Gourlay, L. | Deposit date: | 2019-09-09 | Release date: | 2020-09-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Structure, Immunoreactivity, and In Silico Epitope Determination of SmSPI S. mansoni Serpin for Immunodiagnostic Application. Vaccines (Basel), 9, 2021
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4KDS
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7NPL
| ALPHA-1 ANTITRYPSIN (C232S) COMPLEXED WITH cmpd 11 | Descriptor: | Alpha-1-antitrypsin, GLYCEROL, N-((1S,2R)-1-(3-chloro-2-methylphenyl)-1-hydroxypentan-2-yl)-2-oxoindoline-4-carboxamide | Authors: | Chung, C. | Deposit date: | 2021-02-27 | Release date: | 2021-04-07 | Last modified: | 2021-04-14 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | The development of highly potent and selective small molecule correctors of Z alpha 1 -antitrypsin misfolding. Bioorg.Med.Chem.Lett., 41, 2021
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7NPK
| ALPHA-1 ANTITRYPSIN C232S COMPLEXED WITH CMPD3 | Descriptor: | Alpha-1-antitrypsin, GLYCEROL, N-((1S,2R)-1-hydroxy-1-(o-tolyl)pentan-2-yl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxamide | Authors: | Chung, C. | Deposit date: | 2021-02-27 | Release date: | 2021-04-07 | Last modified: | 2021-04-14 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | The development of highly potent and selective small molecule correctors of Z alpha 1 -antitrypsin misfolding. Bioorg.Med.Chem.Lett., 41, 2021
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5HGC
| A Serpin structure | Descriptor: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, SULFATE ION, ... | Authors: | Das, S, Vashchenko, G.V, Van Petegem, F. | Deposit date: | 2016-01-08 | Release date: | 2016-04-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | A Serpin structure J.Biol.Chem., 2016
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3T1P
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5IO1
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3STO
| Serpin from the trematode Schistosoma Haematobium | Descriptor: | Serine protease inhibitor | Authors: | Granzin, J, Weiergraeber, O.H, Lee, X, Blanton, R.E. | Deposit date: | 2011-07-11 | Release date: | 2012-05-30 | Last modified: | 2013-01-23 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain. Acta Crystallogr.,Sect.D, 68, 2012
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8PI2
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5INW
| Structure of reaction loop cleaved lamprey angiotensinogen | Descriptor: | C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION | Authors: | Wei, H, Zhou, A. | Deposit date: | 2016-03-08 | Release date: | 2016-10-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism J.Biol.Chem., 291, 2016
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8H55
| The structure of zebrafish angiotensinogen | Descriptor: | Angiotensinogen, SULFATE ION | Authors: | Zhou, A, Wei, H. | Deposit date: | 2022-10-12 | Release date: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | BIOLOGICAL IMPLICATIONS OF A 2 ANGSTROMS STRUCTURE OF DIMERIC ANGIOTENSINOGEN To Be Published
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8GXV
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8H4X
| Structure of cleaved Serpin B9 | Descriptor: | 1,2-ETHANEDIOL, Serpin B9, ZINC ION | Authors: | Zhou, A, Yan, T. | Deposit date: | 2022-10-11 | Release date: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Expression, purification and crystallization of cleaved Serpin B9 To Be Published
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8P4U
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8P4J
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7PMU
| Crystal structure of native Iripin-8 | Descriptor: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Serpin-8, ... | Authors: | Polderdijk, S, Kotal, J, Chmelar, J, Huntington, J.A. | Deposit date: | 2021-09-02 | Release date: | 2021-10-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. Int J Mol Sci, 22, 2021
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7ZBF
| Crystal structure of native Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | Iripin-4 serpin, NICKEL (II) ION | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-23 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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3UT3
| A novel PAI-I inhibitor and its structural mechanism | Descriptor: | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione, Plasminogen activator inhibitor 1 | Authors: | Lin, Z.H, Hong, Z.B, Shi, X.L, Hu, L.H, Andreasen, P.A, Huang, M.D. | Deposit date: | 2011-11-25 | Release date: | 2013-02-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | A novel PAI-I inhibitor and its structural mechanism To be Published
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7ZAS
| Crystal structure of cleaved Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | CHLORIDE ION, Iripin-4 serpin | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-22 | Release date: | 2023-03-29 | Last modified: | 2023-05-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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4P0O
| Cleaved Serpin 42Da | Descriptor: | Serine protease inhibitor 4, isoform B | Authors: | Ellisdon, A.M, Whisstock, J.C. | Deposit date: | 2014-02-21 | Release date: | 2014-05-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster. Bmc Struct.Biol., 14, 2014
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