6IBL
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY NB80
Descriptor:Thioredoxin 1,Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, ~{N}-[5-[(1~{R})-2-[[(2~{R})-1-(4-methoxyphenyl)propan-2-yl]amino]-1-oxidanyl-ethyl]-2-oxidanyl-phenyl]methanamide, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-11-30
Release date:2019-01-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
To Be Published
6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-02-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
6MXT
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CRYSTAL STRUCTURE OF HUMAN BETA2 ADRENERGIC RECEPTOR BOUND TO SALMETEROL AND NB71
Descriptor:Endolysin, Beta-2 adrenergic receptor chimera, nanobody Nb71, ...
Authors:Masureel, M., Zou, Y., Picard, L.P., van der Westhuizen, E., Mahoney, J.P., Rodrigues, J.P.G.L.M., Mildorf, T.J., Dror, R.O., Shaw, D.E., Bouvier, M., Pardon, E., Steyaert, J., Sunahara, R.K., Weis, W.I., Zhang, C., Kobilka, B.K.
Deposit date:2018-10-31
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.959342 Å)
Cite:Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
Nat. Chem. Biol., 14, 2018
6IIU
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO RAMATROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IIV
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CRYSTAL STRUCTURE OF THE HUMAN THROMBOXANE A2 RECEPTOR BOUND TO DALTROBAN
Descriptor:Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor, 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]ethanoic acid, ZINC ION, ...
Authors:Fan, H., Zhao, Q., Wu, B.
Deposit date:2018-10-07
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for ligand recognition of the human thromboxane A2receptor.
Nat. Chem. Biol., 15, 2019
6IGK
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH ENDOTHELIN-3
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, Endothelin-3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., Kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IGL
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH IRL1620
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, IRL1620, CITRIC ACID, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6HLL
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CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST CP-99,994
Descriptor:Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, (2~{S},3~{S})-~{N}-[(2-methoxyphenyl)methyl]-2-phenyl-piperidin-3-amine
Authors:Schoppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schutz, M., Dore, A.S., Pluckthun, A.
Deposit date:2018-09-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Nat Commun, 10, 2019
6HLO
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CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST APREPITANT
Descriptor:Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ...
Authors:Schoppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schutz, M., Dore, A.S., Pluckthun, A.
Deposit date:2018-09-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Nat Commun, 10, 2019
6HLP
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CRYSTAL STRUCTURE OF THE NEUROKININ 1 RECEPTOR IN COMPLEX WITH THE SMALL MOLECULE ANTAGONIST NETUPITANT
Descriptor:Substance-P receptor,Substance-P receptor, 2-[3,5-bis(trifluoromethyl)phenyl]-~{N},2-dimethyl-~{N}-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide, CITRIC ACID, ...
Authors:Schoppe, J., Ehrenmann, J., Klenk, C., Rucktooa, P., Schutz, M., Dore, A.S., Pluckthun, A.
Deposit date:2018-09-11
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
Nat Commun, 10, 2019
6MET
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-07
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6MEO
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STRUCTURAL BASIS OF CORECEPTOR RECOGNITION BY HIV-1 ENVELOPE SPIKE
Descriptor:Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, C-C chemokine receptor type 5, ...
Authors:Shaik, M.M., Chen, B.
Deposit date:2018-09-06
Release date:2018-12-12
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of coreceptor recognition by HIV-1 envelope spike.
Nature, 565, 2018
6AKX
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THE CRYSTAL STRUCTURE OF HUMAN CHEMOKINE RECEPTOR CCR5 IN COMPLEX WITH COMPOUND 21
Descriptor:C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION, NITRATE ION, ...
Authors:Zhu, Y., Zhao, Q., Wu, B.
Deposit date:2018-09-04
Release date:2018-10-24
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists.
J. Med. Chem., 61, 2018
6AKY
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THE CRYSTAL STRUCTURE OF HUMAN CHEMOKINE RECEPTOR CCR5 IN COMPLEX WITH COMPOUND 34
Descriptor:C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Zhu, Y., Zhao, Q., Wu, B.
Deposit date:2018-09-04
Release date:2018-10-24
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists.
J. Med. Chem., 61, 2018
6AK3
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP3 BOUND TO PROSTAGLANDIN E2
Descriptor:Prostaglandin E2 receptor EP3 subtype,Soluble cytochrome b562, (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
Authors:Morimoto, K., Suno, R., Iwata, S., Kobayashi, T.
Deposit date:2018-08-29
Release date:2018-12-05
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.
Nat. Chem. Biol., 15, 2019
6M9T
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CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
Descriptor:Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, ...
Authors:Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
Deposit date:2018-08-24
Release date:2018-12-05
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
Nat. Chem. Biol., 15, 2019
6H7J
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY NB80
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, c.g.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7L
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7M
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7N
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6H7O
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY NB6B9
Descriptor:Thioredoxin 1, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T., Edwards, P.C., Dore, A.S., Leslie, A.G.W., Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6E59
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CRYSTAL STRUCTURE OF THE HUMAN NK1 TACHYKININ RECEPTOR
Descriptor:Substance-P receptor, GlgA glycogen synthase, Substance-P receptor chimera, ...
Authors:Yin, J., Clark, L., Chapman, K., Shao, Z., Borek, D., Xu, Q., Wang, J., Rosenbaum, D.M.
Deposit date:2018-07-19
Release date:2018-12-12
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the human NK1tachykinin receptor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DRX
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRY
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.918 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
6DRZ
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STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR
Descriptor:5HT2B receptor, BRIL chimera, CHOLESTEROL, ...
Authors:McCorvy, J.D., Wacker, D., Wang, S., Agegnehu, B., Liu, J., Lansu, K., Tribo, A.R., Olsen, R.H.J., Che, T., Jin, J., Roth, B.L.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
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