9QLM
 
 | Solution structure of the TAF3-PHD bound to a H3K4me3Q5ser histone tail peptide with a serotonylated glutamine | Descriptor: | Histone H3.1, SEROTONIN, Transcription initiation factor TFIID subunit 3, ... | Authors: | van Ingen, H, Gielingh, H, Pulido-Cortes, L, Thijssen, V, Timmers, H.Th.M, Jongkees, S, Honorato, R.V, Bonvin, A.M.J.J, Liu, M, Yoshisada, R, Soares, L.R. | Deposit date: | 2025-03-21 | Release date: | 2025-05-14 | Method: | SOLUTION NMR | Cite: | Molecular determinants for recognition of serotonylated chromatin To Be Published
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9EL8
 
 | LSD1-CoREST in complex with T105 1S2R enantiomer | Descriptor: | 3-[(1R,2S)-2-(cyclobutylamino)cyclopropyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide, Lysine-specific histone demethylase 1A, REST corepressor 1, ... | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2024-12-04 | Release date: | 2025-02-05 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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9ELA
 
 | LSD1-CoREST in complex with T108, long soaking | Descriptor: | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS,13R)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-[3-(phenylcarbamoyl)phenyl]-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2024-12-04 | Release date: | 2025-02-05 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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9EL7
 
 | LSD1-CoREST in complex with T105 enantiomer (1R,2S) | Descriptor: | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S,4R)-5-[(4aS)-7,8-dimethyl-4a-[(1R)-1-{3-[(5-methyl-1,3,4-thiadiazol-2-yl)carbamoyl]phenyl}-3-oxopropyl]-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2024-12-04 | Release date: | 2025-02-05 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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9GP4
 
 | Jumonji domain-containing protein 2A with crystallization epitope mutations Q953E:A958D | Descriptor: | 1,2-ETHANEDIOL, Lysine-specific demethylase 4A, SULFATE ION | Authors: | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | Deposit date: | 2024-09-06 | Release date: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To be published
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9GII
 
 | Jumonji domain-containing protein 2A with crystallization epitope mutation R913A | Descriptor: | GLYCEROL, Lysine-specific demethylase 4A, SULFATE ION | Authors: | Fairhead, M, Strain-Damerell, C, Ye, M, Mackinnon, S.R, Pinkas, D, MacLean, E.M, Koekemoer, L, Damerell, D, Krojer, T, Arrowsmith, C.H, Edwards, A, Bountra, C, Yue, W, Burgess-Brown, N, Marsden, B, von Delft, F, Structural Genomics Consortium (SGC) | Deposit date: | 2024-08-19 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A fast, parallel method for efficiently exploring crystallization behaviour of large numbers of protein variants To be published
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9GD2
 
 | Structure of Chd1 bound to a dinucleosome with a dyad-to-dyad distance of 103 bp. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | Authors: | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | Deposit date: | 2024-08-04 | Release date: | 2024-09-18 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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9GD1
 
 | Structure of Chd1 bound to a hexasome-nucleosome complex with a dyad-to-dyad distance of 103 bp. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | Authors: | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | Deposit date: | 2024-08-04 | Release date: | 2024-09-18 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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9GD3
 
 | Structure of a mononucleosome bound by one copy of Chd1 with the DBD on the exit-side DNA. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | Authors: | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | Deposit date: | 2024-08-04 | Release date: | 2024-09-18 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT. Mol.Cell, 84, 2024
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9FWG
 
 | LSD1/CoREST bound to bomedemstat | Descriptor: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | Authors: | Speranzini, V, Mattevi, A. | Deposit date: | 2024-06-30 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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9C0O
 
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8VOB
 
 | H3K36me3-modified nucleosome bound to PRC2_AJ1-450 | Descriptor: | DNA (157-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Cookis, T, Nogales, E. | Deposit date: | 2024-01-14 | Release date: | 2025-01-15 | Last modified: | 2025-03-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
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8VNZ
 
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8VO0
 
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8VMJ
 
 | H3K4me3 nucleosome bound to PRC2_AJ119-450 | Descriptor: | DNA (157-MER), Histone H2A, Histone H2B, ... | Authors: | Cookis, T, Nogales, E. | Deposit date: | 2024-01-13 | Release date: | 2025-01-15 | Last modified: | 2025-03-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
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8VML
 
 | PRC2_AJ1-450 bound to H3K4me3 | Descriptor: | AEPB2, EED, EZH2, ... | Authors: | Cookis, T, Nogales, E. | Deposit date: | 2024-01-13 | Release date: | 2025-01-15 | Last modified: | 2025-03-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
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8VMI
 
 | PRC2_AJ119-450 bound to H3K4me3 | Descriptor: | EZH2, Histone H3.1, Histone H3.1t, ... | Authors: | Cookis, T, Nogales, E. | Deposit date: | 2024-01-13 | Release date: | 2025-01-15 | Last modified: | 2025-05-28 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
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8VMN
 
 | H3K4me3 nucleosome bound to PRC2_AJ1-450 | Descriptor: | DNA (157-MER), Histone H2A, Histone H2B, ... | Authors: | Cookis, T, Nogales, E. | Deposit date: | 2024-01-13 | Release date: | 2025-01-22 | Last modified: | 2025-03-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
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8VNV
 
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8VLF
 
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8VLD
 
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8VLH
 
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8UOM
 
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8UNI
 
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8UMQ
 
 | LSD1-CoREST in complex with T18, long soaking | Descriptor: | Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-(3-benzamidophenyl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2023-10-18 | Release date: | 2025-02-05 | Method: | X-RAY DIFFRACTION (3.26 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 To Be Published
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